Coordinates of loci of maximum increases in regional cerebral blood flow during chest pain caused by high dose dobutamine compared with baseline (indicated by the highest Z score within each structure)
| Left | Midline | Right | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Brain region | x | y | z | Z score | x | y | z | Z score | x | y | z | Z score |
| Coordinates in the x, y, and z axes of the significant regional cerebral blood flow increases with reference to the stereotactic space defined by the atlas of Talairach and Tournoux.22 Statistical magnitudes are expressed as Z scores. | ||||||||||||
| Syndrome X patients | ||||||||||||
| Lateral orbitofrontal cortex | −28 | 26 | −20 | 7.0 | 24 | 30 | −20 | 7.2 | ||||
| Anterior temporal pole | −22 | 34 | −16 | 6.5 | 30 | 24 | −24 | 7.3 | ||||
| Premotor cortex | −56 | 6 | 20 | 4.6 | ||||||||
| Insula | 40 | 20 | 4 | 3.5 | ||||||||
| Thalamus | −22 | −32 | 8 | 4.1 | ||||||||
| Hypothalamus | −2 | −6 | −24 | 7.1 | ||||||||
| Brain stem | −4 | −96 | −24 | 4.6 | ||||||||
| Controls | ||||||||||||
| Lateral orbitofrontal cortex | −24 | 40 | 0 | 3.9 | ||||||||
| Anterior pole of temporal lobe | −38 | 20 | −28 | 6.9 | 22 | 20 | −28 | 7.3 | ||||
| Insula | −28 | −6 | 20 | 5.9 | ||||||||
| Dorsal cingulate cortex | −8 | −30 | 36 | 5.2 | ||||||||
| Thalamus | −22 | −32 | 16 | 5.1 | 22 | −38 | 8 | 3.9 | ||||
| Cerebellum | −40 | −90 | −30 | 4.7 | ||||||||