Effect of antiarrhythmic agents on sinus rhythm in placebo controlled trials
| Comparators | Number of trials | Follow up* (days), median (range) | Proportion in sinus rhythm at follow up in treatment arm (%), mean (95% CI) | Proportion in sinus rhythm at follow up in control arm (%), mean (95% CI) | Treatment difference† (%), mean (95% CI) | p Value |
|---|---|---|---|---|---|---|
| *Estimates from the control groups; †Percentage difference between treatment and control groups. CI, confidence interval. | ||||||
| IA v Placebo | 7 | 93 (0.04–372) | 54.7 (50.7 to 58.6) | 33.1 (29.2 to 37.0) | 21.5 (16.3 to 26.8) | <0.0001 |
| IC v placebo | 17 | 0.29 (0.04–186) | 60.2 (52.6 to 67.8) | 27.1 (19.6 to 34.6) | 33.1 (23.3 to 42.9) | <0.0001 |
| III v placebo | 19 | 0.33 (0.04–1096) | 46.5 (41.4 to 51.6) | 29.1 (23.9 to 34.4) | 17.4 (11.5 to 23.3) | 0.001 |
| Digoxin v placebo | 4 | 0.58 (0.04–0.75) | 48.4 (31.0 to 65.7) | 35.3 (19.3 to 51.3) | 13.1 (−7.2 to 33.3) | 0.15 |
| IA v III | 6 | 1.0 (0.04–186) | 44.3 (33.0 to 55.6) | 40.1 (29.1 to 51.2) | 4.1 (−8.0 to 16.2) | 0.42 |
| 1C v III | 10 | 0.91 (0.04–372) | 56.7 (45.2 to 68.2) | 60.1 (49.6 to 70.5) | −3.4 (17.2 to 10.5) | 0.6 |
| 1C v IV | 4 | 0.04 (0.04–2.0) | 77.8 (42.7 to 100) | 34.5 (0 to 77.2) | 43.2 (11.5 to 75.0) | 0.03 |
| III v digoxin | 2 | 1 (1–2) | 82.9 (46.8 to 100) | 67.7 (17.6 to 100) | 15.2 (−43.7 to 74.2) | 0.19 |