Effect of antiarrhythmic agents on mortality in placebo controlled trials
| Comparators | Number of trials | Proportion dead at follow up in treatment arm (%), mean (95% CI) | Proportion dead at follow up in control arm (%), mean (95% CI) | Treatment difference (%), mean (95% CI) | p Value |
|---|---|---|---|---|---|
| IA v placebo | 5 | 2.53 (1.41 to 3.64) | 1.57 (0.58 to 2.56) | 0.96 (–0.45 to 2.36) | 0.14 |
| IC v placebo | 14 | 1.20 (1.10 to 1.30) | 1.28 (1.17 to 1.39) | −0.08 (−0.20 to 0.04) | 0.16 |
| III v placebo | 17 | 4.28 (4.06 to 4.50) | 4.39 (4.16 to 4.62) | −0.11 (−0.32 to 0.09) | 0.25 |
| Digoxin v placebo | 4 | 1.76 (1.71 to 1.80) | 1.73 (1.69 to 1.78) | 0.02 (−0.01 to 0.06) | 0.12 |
| IA v III | 5 | 7.29 (6.12 to 8.45) | 7.12 (6.01 to 8.23) | 0.17 (−0.58 to 0.92) | 0.53 |
| IC v III | 8 | 1.76 (1.07 to 2.45) | 2.01 (1.28 to 2.74) | −0.26 (−1.10 to 0.59) | 0.50 |
| IC v IV | 3 | 1.85 (0.53 to 3.17) | 1.91 (0.23 to 3.59) | −0.06 (−2.26 to 2.13) | 0.91 |
| III v digoxin | 2 | 3.29 (0 to 14.37) | 2.82 (0 to 13.26) | 0.48 (−13.71 to 14.67) | 0.74 |