Short term and long term effect of antiarrhythmic agents on sinus rhythm in placebo controlled trials
| Comparators | Follow up duration (days) | Number of trials | Treatment difference (%), mean (95% CI), | p Value |
|---|---|---|---|---|
| 1A v placebo | ≥7 (all studies) | 6 | 21.1 (15.0 to 27.2) | 0.0003 |
| 1C v placebo | <7 | 17 | 31.9 (22.6 to 41.1) | <0.0001 |
| III v placebo | <7 | 12 | 17.3 (9.6 to 25.0) | 0.0002 |
| III v placebo | ≥7 | 3 | 17.6 (3.3 to 31.9) | 0.03 |
| Digoxin v placebo | <7 (all studies) | 4 | 13.1 (−7.2, 33.3) | 0.15 |
| IA v III | <7 | 4 | 12.5 (−29.7 to 33.3) | 0.11 |
| IA v III | ≥7 | 2 | −6.6 (−36.7 to 23.5) | 0.22 |
| IC v III | <7 | 9 | 2.5 (−12.2 to 17.2) | 0.71 |