Skip to main content
Log in

Coronary aneurysms in Kawasaki disease: Follow-up observation by two-dimensional echocardiography

  • Original Articles
  • Published:
Pediatric Cardiology Aims and scope Submit manuscript

Summary

The development and regression of the coronary aneurysms in Kawasaki disease was studied with serial two-dimensional echocardiographic (2D echo) examinations. The diameter of the aneurysms at the proximal portions of the left coronary artery was measured on the 2D echo images in ten patients with Kawasaki disease, in whom left coronary aneurysms were found at the acute stage of the illness, and followed by 2D echo for longer than eight months. It was found that coronary aneurysms usually developed during the second week of the illness, reached maximal size at 3–8 weeks, and regressed gradually thereafter. Small aneurysms disappeared in several months, and those of intermediate size regressed in one to two years. Large aneurysms may remain for many years. Mural thrombi within the aneurysms were detected with 2D echo in three patients. They decreased in echodensity and eventually disappeared echographically.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dean AG, Melish ME, Hicks R, Palumbo NE (1982) An epidemic of Kawasaki syndrome in Hawaii.J Pediatr 100:552–557

    Google Scholar 

  2. Fujiwara H, Hamashima Y (1978) Pathology of the heart in Kawasaki disease.Pediatrics 61:100–107

    Google Scholar 

  3. Hiraishi S, Yashiro K, Kusano S (1979) Noninvasive visualization of coronary arterial aneurysm in infants and young children with mucocutaneous lymph node syndrome with two-dimensional echocardiography.Am J Cardiol 43:1225–1233

    Google Scholar 

  4. Hiraishi S, Yashiro K, Oguchi K, Kusano S, Ishii K, Nakazawa K (1981) Clinical course of cardiovascular involvement in the mucocutaneous lymph node syndrome: relation between clinical signs of carditis and development of coronary arterial aneurysm.Am J Cardiol 47:323–330

    Google Scholar 

  5. Hirose O, Misawa H, Kijima Y, Yamada O, Arakaki Y, Kajino Y, Ryujin Y, Kowata T, Echigo S, Kamiya T (1981) Two-dimensional echocardiography of coronary artery in Kawasaki disease (MCLS): detection, changes in acute phase and follow-up observation of the aneurysm [in Japanese].J Cardiogr 11:89–104

    Google Scholar 

  6. Ichinose E, Eto Y, Takechi T, Yoshioka F, Kato H (1982) Two-dimensional echocardiographic study of coronary artery lesion in Kawasaki disease: a new approach to visualize the right coronary artery [in Japanese].J Cardiogr 12:111–124

    Google Scholar 

  7. Itoh S (1980) Two-dimensional echocardiographic diagnosis of coronary aneurysms in Kawasaki disease: correlation between angiographic and echocardiographic findings.Nihon Univ J Med 22:291–302

    Google Scholar 

  8. Kamiya T, Suzuki A, Kijima Y, Hirose O, Takahashi O (1982) Coronary arterial lesion in Kawasaki disease: occurrence and prognosis [in Japanese].Rec Adv Cardiovasc Dis 3:19–27

    Google Scholar 

  9. Kato H, Koike S, Yokoyama T (1979) Kawasaki disease: effect of treatment on coronary artery involvement.Pediatrics 63:175–179

    Google Scholar 

  10. Kato H, Ichinose E, Yoshioka F, Takechi T, Matsunaga S, Suzuki K, Rikitake N (1982) Fate of coronary aneurysms in Kawasaki disease: serial coronary angiography and long-term follow-up study.Am J Cardiol 49:1758–1766

    Google Scholar 

  11. Kawasaki T (1967) Mucocutaneous lymph node syndrome: clinical observations of 50 cases [in Japanese].Jpn J Allergol 16:178–222

    Google Scholar 

  12. Kawasaki T, Kosaki F, Okawa S, Shigematsu I, Yanagawa H (1974) A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan.Pediatrics 54:271–276

    Google Scholar 

  13. Kusakawa S (1980) Report from the research team on prevention against sudden death from Kawasaki disease [in Japanese].Acta Pediatr Jpn 84:908–910

    Google Scholar 

  14. Kusakawa S, Yanagisawa M (1977) Cardiac involvement in Kawasaki disease (MCLS). In:1976 Annual report from the research team on chronic diseases in childhood (sponsored by the Ministry of Health and Welfare of Japan) [in Japanese]. Tokyo, pp 71–73

  15. Landing BH, Larson EJ (1977) Are infantile periarteritis nodosa with coronary artery involvement and fatal mucocutaneous lymph node syndrome the same? Comparison of 20 patients from North America with patients from Hawaii and Japan.Pediatrics 59:651–662

    Google Scholar 

  16. MCLS Research Committee (1983) Recent trend of MCLS (Kawasaki disease) in Japan: provisional reports of the 7th nationwide survey [in Japanese].Pediatr Jpn 24:53–58

    Google Scholar 

  17. Meade RH III, Brandt L (1982) Manifestations of Kawasaki disease in New England outbreak of 1980.J Pediatr 100:558–562

    Google Scholar 

  18. Melish ME, Hicks RM, Larson EJ (1976) Mucocutaneous lymph node syndrome in the United States.Am J Dis Child 130:599–607

    Google Scholar 

  19. Morens DM, Anderson LJ, Hurwitz ES (1980) National surveillance of Kawasaki disease.Pediatrics 65:21–25

    Google Scholar 

  20. Morikawa Y, Osano M, Oikawa T, Kimura K, Kojima Y, Wakabayashi R, Hayano S, Toujo M, Tsuji A, Kohri T, Mizoi K (1983) Diameter of the left and right coronary arteries in normal children: two-dimensional echocardiographic measurement [in Japanese].Jpn J Pediatr 36:448–452

    Google Scholar 

  21. Teixeira OHF, Martin L, Carpenter BF, Sellers FJ (1980) Kawasaki disease, or mucocutaneous lymph node syndrome: report of seven cases in North America.Can Med Assoc J 122:1013–1018

    Google Scholar 

  22. Vangrov MS, Kangarloo H, Di Sessa TG, Isabel-Jones JB, Heins H (1981) Ultrasonography of mucocutaneous lymph node syndrome.Radiology 139:166

    Google Scholar 

  23. Yoshida H, Funabashi T, Nakaya S, Taniguchi N (1979) Mucocutaneous lymph node syndrome: a cross-sectional echocardiographic diagnosis of coronary aneurysms.Am J Dis Child 133:1244–1247

    Google Scholar 

  24. Yoshida H, Maeda T, Funabashi T, Nakaya S, Takabatake S, Taniguchi N (1982) Subcostal two-dimensional echocardiographic imaging of peripheral right coronary artery in Kawasaki disease.Circulation 65:956–961

    Google Scholar 

  25. Yoshikawa J, Yanagihara K, Owaki T, Kato H, Takagi Y, Okumachi F, Fukaya T, Tomita Y, Baba K (1979) Cross-sectional echocardiographic diagnosis of coronary artery aneurysms in patients with the mucocutaneous lymph node syndrome.Circulation 59:133–139

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yanagisawa, M., Yano, S., Shiraishi, H. et al. Coronary aneurysms in Kawasaki disease: Follow-up observation by two-dimensional echocardiography. Pediatr Cardiol 6, 11–16 (1985). https://doi.org/10.1007/BF02265402

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02265402

Key words

Navigation