Summary
Supine exercise equilibrium radionuclide right ventriculography was performed in 13 children (8–18 years) with hypercholesterolemia. Phase analysis was used to construct right ventricular regions of interest, and a peri-right ventricular region was used for background correction. Right ventricular ejection fraction at rest and exercise was 50.5±9.2% and 61.5±8.1%, respectively, with a mean increase of 11.0±7.5 percentage units (range 1–27 percentage units). During exercise, end-diastolic volume remained unchanged while end-systolic volume decreased by 19.4%, producing a 21.7% increase in stroke volume. Stroke volume ratios (left ventricular stroke volume counts/right ventricular stroke volume counts) approach unity (1.00±0.27). However, interobserver and intraobserver correlations are just fair, implying only a modest degree of accuracy and reliability of the procedure. This imprecision needs to be considered when evaluating the results of nuclear equilibrium right ventriculography.
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References
Berger HJ, Matthay R (1981) Radionuclide right ventricular ejection fraction: applications in valvular heart disease [letter].Chest 79:497–498
Berger HJ, Matthay RA, Loke J, Marshall RC, Gottschalk A, Zaret BL (1978) Assessment of cardiac performance with quantitative radionuclide angiography: right ventricular ejection fraction with references to findings in chronic obstructive pulmonary disease.Am J Cardiol 41:897–905
Botvinick E, Dunn R, Frais M, O'Connell W, Shosa D, Herfkens R, Scheinman M (1982) The phase image: its relationship to patterns of contraction and conduction.Circulation 65:551–560
DeSouza M, Schaffer MS, Gilday DL, Rose V (1984) Exercise radionuclide angiography in hyperlipidaemic children with apparently normal hearts.Nucl Med Commun 5:13–17
Guiteras P, Green M, DeSouza M, Gilday D, Olley P (1985) Count-based scintigraphic method to calculate ventricular volumes in children: in vitro and clinical validation.J Am Coll Cardiol 5:963–972
Holman BL, Wynne J, Zielonka JS, Idoine JD (1981) A simplified technique for measuring right ventricular ejection fraction using the equilibrium radionuclide angiocardiogram and the slant-hole collimator.Radiology 138:429–435
Maddahi J, Berman DS, Matsuoka DT, Waymana D, Stankus KE, Forrester JS, Swan HJC (1979) A new technique for assessing right ventricular ejection fraction using rapid multiple-gated equilibrium cardiac blood pool scintigraphy: description, validation and findings in chronic coronary artery disease.Circulation 60:581–589
Maddahi J, Berman DS, Matsuoka DT, Waxman AD, Forrester JS, Swan HJC (1980) Right ventricular ejection fraction during exercise in normal subjects and in coronary artery disease patients: assessment by multiple-gated equilibrium scintigraphy.Circulation 62:133–140
Manno BV, Iskandrian AS, Hakki A (1984) Right ventricular function: methodologic and clinical considerations in noninvasive scintigraphic assessment.J Am Coll Cardiol 3:1072–1082
Morrison D, Marshall J, Wright AL, Daly M, Henry R (1980) An improved method of right ventricular gated equilibrium blood pool radionuclide ventriculography.Chest 82:607–614
Morrison D, Sorensen S, Caldwell J, Wright AL, Ritchie J, Kennedy JW, Hamilton G (1982) The normal right ventricular response to supine exercise.Chest 82:686–691
Nienaber CA, Spielmann RP, Wasmus G, Mathey DG, Montz R, Bleifeld WH (1985) Clinical use of ultrashort-lived radionuclide krypton-81m for noninvasive analysis of right ventricular performance in normal subjects and patients with right ventricular dysfunction.J. Am Coll Cardiol 5:687–698
Parrish M, Graham T Jr, Born M, Jones J (1982) Radionuclide evaluation of right and left ventricular function in children: validation of methodology.Am J Cardiol 49:1241–1247
Parrish MD, Boucek RJ Jr, Burger J, Artman MF, Partain CL, Graham TP Jr (1985) Exercise radionuclide ventriculography in children: normal values for exercise variables and right and left ventricular function.Br Heart J 54:509–516
Pavel D, Swiryn S, Lam W, Byrom E, Sheikh A, Rosen K (1980) Ventricular phase analysis of radionuclide gated studies [abstr].Am J Cardiol 45:398
Schaffer M, Gilday D, DeSouza M, Rose V, Regelink E, Rowe R (1983) Exercise radionuclide angiography with phase analysis in children with familial hypercholesterolemia [abstr].J Nucl Med 24:P32
Schaffer MS, de Souza M, Olley PM, Rowe RD, Gilday DL (1984) Qualitative phase analysis in pediatric nuclear cardiology: isolation of cardiac chambers and identification of asynchronous contraction patterns.Pediatr Cardiol 5:179–184
Slutsky R, Hooper W, Gerber K, Battler A, Froelicher V, Ashburn W, Karliner J (1980) Assessment of right ventricular function at rest and during exercise in patients with coronary heart disease: a new approach using equilibrium radionuclide angiography.Am J Cardiol 45:63–71
Tobinick E, Schelbert HR, Henning H, Lewinter M, Taylor A, Ashburn W, Karliner JS (1977) Right ventricular ejection fraction in patients with acute anterior and inferior myocardial infarction assessed by radionuclide angiography.Circulation 57:1078–1084
Verba JW, Bornstein I, Alazraki NP, Taylor A, Bhargava V, Shabetai R, Lewinter M (1979) Onset and progression of mechanical systole derived from gated radionuclide techniques and displayed in cine format [abstr].J Nucl Med 20:625–626
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Schaffer, M.S., de Souza, M., Gilday, D.L. et al. Exercise radionuclide right ventriculography in children. Pediatr Cardiol 8, 235–240 (1987). https://doi.org/10.1007/BF02427535
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DOI: https://doi.org/10.1007/BF02427535