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Roles of oxidative stress in signaling and inflammation induced by particulate matter

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Abstract

This review reports the role of oxidative stress in impairing the function of lung exposed to particulate matter (PM). PM constitutes a heterogeneous mixture of various types of particles, many of which are likely to be involved in oxidative stress induction and respiratory diseases. Probably, the ability of PM to cause oxidative stress underlies the association between increased exposure to PM and exacerbations of lung disease. Mostly because of their large surface area, ultrafine particles have been shown to cause oxidative stress and proinflammatory effects in different in vivo and in vitro studies. Particle components and surface area may act synergistically inducing lung inflammation. In this vein, reactive oxygen species elicited upon PM exposure have been shown to activate a number of redox-responsive signaling pathways and Ca2+ influx in lung target cells that are involved in the expression of genes that modulate relevant responses to lung inflammation and disease.

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References

  • Abidi P, Afaq F, Arif JM, Lohani M, Rahman Q. Chrysotile-mediated imbalance in the glutathione redox system in the development of pulmonary injury. Toxicol Lett. 1999;106:31–9.

    Article  PubMed  CAS  Google Scholar 

  • Adler V, Yin Z, Tew KD, Ronai Z. Role of redox potential and reactive oxygen species in stress signaling. Oncogenese. 1999;18:6104–11.

    Article  CAS  Google Scholar 

  • Afaq F, Abidi P, Rahman Q. N-acetyl L-cysteine attenuates oxidant-mediated toxicity induced by chrysotile fibers. Toxicol Lett. 2000;117:53–60.

    Article  PubMed  CAS  Google Scholar 

  • Anderson HR, Bremmer SA, Atkinson RW, Harrison RM, Walters S. Particulate matter and daily mortality and hospital admissions in the west midlands conurbation of the United Kingdom: associations with fine and coarse particles, black smoke and sulphate. Occup Environ Med. 2001;58:504–10.

    Article  PubMed  CAS  Google Scholar 

  • Andreadis AA, Hazen SL, Comhair SAA, Erzurum SC. Role of reactive oxygen and nitrogen species (ROS/RNS) in lung injury and diseases. Free Radic Biol Med. 2003;35:213–25.

    Article  PubMed  CAS  Google Scholar 

  • Anseth JW, Goffin AJ, Fuller GG, Ghio AJ, Kao PN, Upadhyay D. Lung surfactant gelation induced by epithelial cells exposed to air pollution or oxidative stress. Am J Respir Cell Mol Biol. 2005;33:161–8.

    Article  PubMed  CAS  Google Scholar 

  • Arbex MA, Böhm GM, Saldiva PHN, Conceição GMS. Assessment of the effects of sugar cane plantation burning on daily counts of inhalation therapy. J Air Waste Manage Assoc. 2000;50:1745–9.

    CAS  Google Scholar 

  • Arbex MA, Cançado JED, Pereira LAA, Braga ALF, Saldiva PHN. Queima de biomassa e efeitos sobre a saúde. J Bras Pneumol. 2004;30:158–75.

    Article  Google Scholar 

  • Arbex MA, Martins LC, De Oliveira RC, Pereira LA, Cançado JE, Saldiva PH, et al. Air pollution from biomass burning and asthma hospital admissions in a sugar cane plantation area in Brazil. J Epidemiol Community Health. 2007;61:395–400.

    Article  PubMed  Google Scholar 

  • Arredouani MS, Palecanda A, Koziel H, Huang Y-C, Imrich A, Sulahian TH, et al. MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. J Immunol. 2005;175:6058–64.

    PubMed  CAS  Google Scholar 

  • ATSDR, Agency for Toxic Substances and Disease Registry. Health consultation—dioxin and polycyclic aromatic hydrocarbon chemical signatures (fingerprints) in sediments 2006; http://www.atsdr.cdc.gov/HAC/pha/StLouisRiverUSSteel/StLouisRiver-USSteelSiteHC093006.pdf.

  • Baeza-Squiban A, Bonvallot V, Boland S, Marano F. Airborne particles evoke an inflammatory response in human airway epithelium. Activation of transcription factors. Cell Biol Med. 1999;31:1132–8.

    Google Scholar 

  • Bagci C, Bozkurt AI, Cakmak EA, Can S, Cengiz B. Blood lead levels of the battery and exhaust workers and their pulmonary function tests. Int J Clin Pract. 2004;58:568–72.

    Article  PubMed  CAS  Google Scholar 

  • Bateson TF, Schwartz J. Children’s response to air pollutants. J Toxicol Environ Health A. 2008;71:238–43.

    Article  PubMed  CAS  Google Scholar 

  • Baulig A, Garlatti M, Bonvallot V, Marchand A, Barouki R, Marano F, et al. Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2003;285:L671–9.

    PubMed  CAS  Google Scholar 

  • Beamer CA, Holian A. Scavenger receptor class A type I/II (CD204) null mice fail to develop fibrosis following silica exposure. Am J Physiol Lung Cell Mol Physiol. 2005;289:L186–95.

    Article  PubMed  CAS  Google Scholar 

  • Becher R, Bucht A, Ovrevik J, Hongslo JK, Dahlman HJ, Samuelsen JT, et al. Involvement of NADPH oxidase and iNOS in rodent pulmonary cytokine responses to urban air and mineral particles. Inhal Toxicol. 2007;19:645–55.

    Article  PubMed  CAS  Google Scholar 

  • Becker S, Soukup JM, Gallagher JE. Differential particulate air pollution induced oxidant stress in human granulocytes, monocytes and alveolar macrophages. Toxicol In Vitro. 2002;16:209–18.

    Article  PubMed  CAS  Google Scholar 

  • Berridge MJ, Bootman MD, Lipp P. Calcium—a life and death signal. Nature. 1998;395:645–8.

    Article  PubMed  CAS  Google Scholar 

  • Bérubé K, Balharry D, Sexton K, Koshy L, Jones T. Combustion-derived nanoparticles: mechanisms of pulmonary toxicity. Clin Exp Pharmacol Physiol. 2007;34:1044–50.

    Article  PubMed  CAS  Google Scholar 

  • Bonner JC, Rice AB, Moomaw CR, Morgan DL. Airway fibrosis in rats induced by vanadium pentoxide. Am J Physiol Lung Cell Mol Physiol. 2000;278:L209–16.

    PubMed  CAS  Google Scholar 

  • Bonvallot V, Baeza-Squiban A, Baulig A, Brulant S, Boland S, Muzeau F, et al. Organic compounds from diesel exhaust particles elicit a proinflammatory response in human airway epithelial cells and induce cytochrome p450 1A1 expression. Am J Respir Cell Mol Biol. 2001;25:515–21.

    PubMed  CAS  Google Scholar 

  • Boojar MM, Goodarzi F. A longitudinal follow-up of pulmonary function and respiratory symptoms in workers exposed to manganese. J Occup Environ Med. 2002;44:282–90.

    Article  PubMed  CAS  Google Scholar 

  • Braback L, Forsberg B. Does traffic exhaust contribute to the development of asthma and allergic sensitization in children: findings from recent cohort studies. Environ Health. 2009;8:17.

    Article  PubMed  CAS  Google Scholar 

  • Braga ALF, Zanobetti A, Schwartz J. Do respiratory epidemics confound the association between air pollution and daily deaths? Eur Respir J. 2000;16:723–8.

    Article  PubMed  CAS  Google Scholar 

  • Braga ALF, Saldiva PHN, Pereira LAA, Menezes JJC, Conceição GMS, Lin CL, et al. Health effects of air pollution exposure on children and adolescents in Sao Paulo, Brazil. Pediatr Pulmonol. 2001;31:106–13.

    Article  PubMed  CAS  Google Scholar 

  • Brown DM, Stone V, Findlay P, MacNee W, Donaldson K. Increased inflammation and intracellular calcium caused by ultrafine carbon black is independent of transition metals or other soluble components. Occup Environ Med. 2000;57:685–91.

    Article  PubMed  CAS  Google Scholar 

  • Brown DW, Wilson MR, MacNee W, Stone V, Donaldson K. Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol Appl Pharmacol. 2001;175:191–9.

    Article  PubMed  CAS  Google Scholar 

  • Brown DM, Donaldson K, Borm PJ, Schins RP, Dehnhardt M, Gilmour P, et al. Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles. Am J Physiol Lung Cell Mol Physiol. 2004;286:L344–53.

    Article  PubMed  CAS  Google Scholar 

  • Brown DM, Hutchison L, Donaldson K, Stone V. The effects of PM10 particles and oxidative stress on macrophages and lung epithelial cells: modulating effects of calcium-signaling antagonists. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1444–51.

    Article  PubMed  CAS  Google Scholar 

  • Cançado JED, Saldiva PHN, Pereira LAA, Lara LBLS, Artaxo P, Martinelli LA, et al. The impact of sugar cane-burning emissions on the respiratory system of children and the elderly. Environ Health Perspect. 2006;114:725–9.

    Article  PubMed  CAS  Google Scholar 

  • Cardile V, Renis R, Scifo C, Lombardoa L, Gulino R, Mancari B, et al. Behaviour of the new asbestos amphibole fluoro-edenite in different lung cell systems. Int J Biochem Cell Biol. 2004;36:849–60.

    Article  PubMed  CAS  Google Scholar 

  • Carpentier I, Declercq W, Malinin NL, Wallach D, Fiers W, Beyaert R. TRAF2 plays a dual role in NF-kappaB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IkappaB kinase pathways. FEBS Lett. 1998;425:195–8.

    Article  PubMed  CAS  Google Scholar 

  • Castaño-Vinyals C, D’errico A, Malats N, Kogevinas M. Biomarkers of exposure to polycyclic aromatic hydrocarbons from environment air pollution. Occup Environ Med. 2004;61:e12.

    Article  PubMed  Google Scholar 

  • Churg A, Xie C, Wang X, Vincent R, Wang RD. Air pollution particles activate NF-κB on contact with airway epithelial cell surfaces. Toxicol Appl Pharmacol. 2005;208:37–45.

    Article  PubMed  CAS  Google Scholar 

  • Cifuentes LA, Vega J, Köpfer K. Effect of the fine fraction of particulate matter versus the coarse mass and other pollutants in daily mortality in Santiago, Chile. J Air Waste Manage Assoc. 2000;50:1287–98.

    CAS  Google Scholar 

  • Clarke RW, Catalano PJ, Krishna Murty GG, Sioutas C, Paulaukis J, Coull B, et al. Urban air particulate inhalation alters pulmonary function and induces pulmonary inflammation in a rodent model of chronic bronchitis. Toxicol. 1999;11:637–56.

    CAS  Google Scholar 

  • Clarke RW, Coull B, Reinisch U, Catalano PJ, Killingsworth C, Koutrakis P, et al. Inhaled concentrated ambient particles are associated with hematological and bronchoalveolar lavage changes in canines. Environ Health Perspect. 2000;108:1179–87.

    Article  PubMed  CAS  Google Scholar 

  • Comhair SA, Bhathena PR, Dweik RA, Kavuru M, Erzurum SC. Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response. Lancet. 2000;355:624.

    Article  PubMed  CAS  Google Scholar 

  • Comhair SA, Bhathena PR, Farver C, Thunnissen FB, Erzurum SC. Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells. FASEB J. 2001;15:70–8.

    Article  PubMed  CAS  Google Scholar 

  • Conway JD, Bortolotta T, Abdullah LH, Davis CW. Regulation of mucin secretion from human bronchial epithelial cells grown in murine hosted xenografts. Am J Physiol, Lung Cell Mol Physiol. 2003;284:L945–54.

    CAS  Google Scholar 

  • Cupitt LT, Glen WG, Lewtas J. Exposure and risk from ambient particle-bound pollution in an airshed dominated by residential wood combustion and mobile sources. Environ Health Perspect. 1994;102:75–84.

    Article  PubMed  CAS  Google Scholar 

  • Cuschieri J, Gourlay D, Garcia I, Jelacie S, Maier RV. Slow channel calcium inhibition blocks proinflammatory gene signaling and reduces macrophage responsiveness. J Trauma. 2002;52:434–42.

    Article  PubMed  CAS  Google Scholar 

  • Dagher Z, Garçon G, Billet S, Gosset P, Ledoux F, Courcot D, et al. Activation of different pathways of apoptosis by air pollution particulate matter (PM2.5) in human epithelial lung cells (L132) in culture. Toxicol. 2006;225:12–24.

    Article  CAS  Google Scholar 

  • Dagher Z, Garçon G, Billet S, Verdin A, Ledoux F, Courcot D, et al. Role of nuclear factor-kappa B activation in the adverse effects induced by air pollution particulate matter (PM2.5) in human epithelial lung cells (L132) in culture. J Appl Toxicol. 2007;27:284–90.

    Article  PubMed  CAS  Google Scholar 

  • Dales R, Miller D, Ruest K, Guay M, Judek S. Airborne endotoxin is associated with respiratory illness in the first 2 years of life. Environ Health Perspect. 2006;114:610–4.

    Article  PubMed  CAS  Google Scholar 

  • Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Particulate air pollution and mortality in the United States: did the risks change from 1987 to 2000? Am J Epidemiol. 2007;166:880–8.

    Article  PubMed  Google Scholar 

  • Donaldson K, Stone V. Current hypotheses on the mechanisms of toxicity of ultrafine particles. Ann Ist Super Sanità. 2003;39:405–10.

    PubMed  CAS  Google Scholar 

  • Donaldson K, Stone V, Clouter A, Renwick L, MacNee W. Ultrafine particles. Occup Environ Med. 2001;58:211–6.

    Article  PubMed  CAS  Google Scholar 

  • Donaldson K, Brown D, Clouter A, Duffin R, MacNee W, Renwick L, et al. The pulmonary toxicology of ultrafine particles. J Aerosol Med. 2002;15:213–20.

    Article  PubMed  CAS  Google Scholar 

  • Donaldson K, Stone V, Borm PJA, Jimenez LA, Gilmour PS, Schins RPF, et al. Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10). Free Radic Biol Med. 2003;34:1369–82.

    Article  PubMed  CAS  Google Scholar 

  • Donaldson K, Tran L, Jimenez LA, Duffin R, Newby DE, Mills N, et al. Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure. Part Fibre Toxicol. 2005;2:10.

    Article  PubMed  CAS  Google Scholar 

  • Dopp E, Yadav S, Ansari FA, Bhattacharya K, von Recklinghausen U, Rauen U, et al. ROS-mediated genotoxicity of asbestos-cement in mammalian lung cells in vitro. Part Fibre Toxicol. 2005;6:2–9.

    Google Scholar 

  • Douwes J, Zuidhof A, Doekes G, van der Zee S, Wouters I, Boezen HM, et al. (1→3)-β-D-Glucan and endotoxin in house dust and peak flow variability in children. Am J Respir Crit Care Med. 2000;162:1348–54.

    PubMed  CAS  Google Scholar 

  • Dreher K. Particulate matter physicochemistry and toxicology; in search of causality—a critical perspective. Inhal Toxicol. 2000;12:45–57.

    Article  CAS  Google Scholar 

  • Duffin R, Tran CL, Clouter A, Brown DM, MacNee W, Stone V, et al. The importance of surface area and specific reactivity in the acute pulmonary inflammatory response to particles. Ann Occup Hyg. 2002;46:242–5.

    Google Scholar 

  • Duffin R, Mills NL, Donaldson K. Nanoparticles—a thoracic toxicology perspective. Yonsei Med J. 2007a;48:561–72.

    Article  PubMed  CAS  Google Scholar 

  • Duffin R, Tran L, Brown D, Stone V, Donaldson K. Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity. Inhal Toxicol. 2007b;19:849–56.

    Article  PubMed  CAS  Google Scholar 

  • Dusseldorp A, Kruise H, Brunekreef B, Hofschreuder P, Meer G, Van Oudvorst AB. Associations of PM10 and airborne iron with respiratory health of adults living near a steel factory. Am J Respir Crit Care Med. 1995;152:1932–9.

    PubMed  CAS  Google Scholar 

  • Dworski R. Oxidant stress in asthma. Thorax. 2000;55:S51–3.

    Article  PubMed  Google Scholar 

  • Dye JA, Adler KB, Richards JH, Dreher KL. Role of soluble metals in oil fly ash-induced airway epithelial injury and cytokine gene expression. Am J Physiol. 1999;277:L498–510.

    PubMed  CAS  Google Scholar 

  • Ermak G, Davies KJA. Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol. 2002;38:713–21.

    Article  PubMed  CAS  Google Scholar 

  • Etzel RA. How environmental exposure influence the development and exacerbation of asthma. Pediatrics. 2003;112:233–9.

    PubMed  Google Scholar 

  • Fahmy B, Cormier SA. Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells. Toxicology In Vitro. 2009;23:1365–71.

    Article  PubMed  CAS  Google Scholar 

  • Farhat SCL, Paulo RLP, Shimoda TM, Conceição GMS, Lin CA, Braga ALF, et al. Effect of air pollution on pediatric respiratory emergency room visits and hospital admissions. Braz J Med Biol Res. 2005;38:227–35.

    Article  PubMed  CAS  Google Scholar 

  • Faux SP, Howden PJ, Levy LS. Iron-dependent formation of 8-hydroxydeoxyguanosine in isolated DNA and mutagenicity in Salmonella typhimurium TA102 induced by crocidolite. Carcinogenesis. 1994;15:1749–51.

    Article  PubMed  CAS  Google Scholar 

  • Forman HJ, Torres M. Redox signaling in macrophages. Mol Aspects Med. 2001;22:189–216.

    Article  PubMed  CAS  Google Scholar 

  • Frye C, Hoelscher B, Cyrys J, Wjst M, Wichmann HE, Heinrich J. Association of lung function with declining ambient air pollution. Environ Health Perspect. 2003;111:383–7.

    Article  PubMed  Google Scholar 

  • Fusco D, Forastiere F, Michelozzi P, Spadea T, Ostro B, Arcà M, et al. Air pollution and hospital admissions for respiratory conditions in Rome, Italy. Eur Respir J. 2001;17:1143–50.

    Article  PubMed  CAS  Google Scholar 

  • Gehring U, Bolte G, Borte M, Bischof W, Fahlbusch B, Wichmann HE, et al. Exposure to endotoxin decreases the risk of atopic eczema in infancy: a cohort study. J Allergy Clin Immunol. 2001;108:847–54.

    Article  PubMed  CAS  Google Scholar 

  • Ghio AJ, Devlin RB. Inflammatory lung injury after bronchial instillation of air pollution particles. Am J Respir Crit Care Med. 2001;164:704–8.

    PubMed  CAS  Google Scholar 

  • Ghio AJ, Kennedy TP, Stonehuerner J, Carter JD, Skinner KA, Parks DA, et al. Iron regulates xanthine oxidase activity in the lung. Am J Physiol Lung Cell Mol Physiol. 2002;283:L563–72.

    PubMed  CAS  Google Scholar 

  • Ghio AJ, Kim C, Devlin RB. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am J Respir Crit Care Med. 2000;162:981–8.

    PubMed  CAS  Google Scholar 

  • Gilmour PS, Rahman I, Hayashi S, Hogg JC, Donaldson K, MacNee W. Adenoviral E1A primes alveolar epithelial cells to PM10-induced transcription of interleukin-8. Am J Physiol, Lung Cell Mol Physiol. 2001;281:L598–606.

    CAS  Google Scholar 

  • Gilmour MI, Jaakkola MS, London SJ, Nel AE, Rogers CA. How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma. Environ Health Perspect. 2006;114:627–33.

    Article  PubMed  CAS  Google Scholar 

  • Goldsmith C-A, Frevert C, Imrich A, Sioutas C, Kobzik L. Alveolar macrophage interaction with air pollution particulates. Environ Health Perspect. 1997;105:1191–5.

    Article  PubMed  CAS  Google Scholar 

  • Goldsmith CA, Imrich A, Danaee H, Ning YY, Kobzik L. Analysis of air pollution particulate-mediated oxidant stress in alveolar macrophages. J Toxicol Environ Health A. 1998;54:529–45.

    Article  PubMed  CAS  Google Scholar 

  • González-Flecha B. Oxidant mechanism in response to ambient air particles. Mol Aspects Med. 2004;25:169–82.

    Article  PubMed  CAS  Google Scholar 

  • Grievink L, Smit HA, Brunekreef B. Anti-oxidants and air pollution in relation to indicators of asthma and COPD: a review of the current evidence. Clin Exp Allergy. 2000;30:1344–54.

    Article  PubMed  CAS  Google Scholar 

  • Grover AK, Samson SE, Fomin VP. Peroxide inactivates calcium pumps in pig coronary artery. Am J Physiol Heart Circ Physiol. 1992;263:H537–43.

    CAS  Google Scholar 

  • Gurgueira SA, Lawrence J, Coull B, Krishna Murthy GG, Gonzáles-Flecha B. Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environ Health Perspect. 2002;110:749–55.

    Article  PubMed  CAS  Google Scholar 

  • Haller T, Ortmayr J, Friedrich F, Volkl H, Dielt P. Dynamics of surfactant release in alveolar type II cells. Proc Natl Acad Sci USA. 1998;95:1579–84.

    Article  PubMed  CAS  Google Scholar 

  • Harrison RM, Yin J. Particulate matter in the atmosphere: which particle properties are important for its effects on health? Sci Total Environ. 2000;249:85–101.

    Article  PubMed  CAS  Google Scholar 

  • Harrison RM, Shi JP, Xi S, Khan A, Mark D, Kinnersley R, et al. Measurement of number, mass and size distribution of particles in the atmosphere. Phil Trans R Soc Lond A. 2000;358:2567–80.

    Article  CAS  Google Scholar 

  • Hashimoto S, Gon Y, Takeshita I, Matsumoto K, Jibiki I, Takizawa H, et al. Diesel exhaust particles activate p38 MAP kinase to produce interleukin 8 and RANTES by human bronchial epithelial cells and N-acetylcysteine attenuates p38 map kinase activation. Am J Respir Crit Care Med. 2000;161:280–5.

    PubMed  CAS  Google Scholar 

  • Helfand WH, Lazarus J, Theerman P. Donora, Pennsylvania: an environmental disaster of the 20th century. Am J Public Health. 2001;91:553.

    Article  PubMed  CAS  Google Scholar 

  • Heming TA, Dave SK, Tuazon DM, Chopra AK, Peterson JW, Bidani A. Effects of extracellular pH on tumor necrosis factor-α production by resident alveolar macrophages. Clin Sci. 2001;101:267–74.

    Article  PubMed  CAS  Google Scholar 

  • Hitchins J, Morawska L, Wolff R, Gilbert D. Concentrations of submicrometre particles from vehicle emissions near a major road. Atmosph Environ. 2000;34:51–9.

    Article  CAS  Google Scholar 

  • Hiura TS, Kaszubowski MP, Li N, Nel AE. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J Immunol. 1999;163:5582–91.

    PubMed  CAS  Google Scholar 

  • Hong YC, Hwang SS, Kim JH, Lee KH, Lee HJ, Lee KH, et al. Metals in particulate pollutants affect peak expiratory flow of schoolchildren. Environ Health Perspect. 2007;115:430–4.

    Article  PubMed  CAS  Google Scholar 

  • Howden PJ, Faux SP. Fibre induced lipid peroxidation leads to DNA adduct formation in Salmonella typhimurium TA104 and rat lung fibroblast. Carcinogenesis. 1996;17:413–9.

    Article  PubMed  CAS  Google Scholar 

  • Hoyal CR, Giron-Calle J, Forman HJ. The alveolar macrophage as a model of calcium signaling in oxidative stress. J Toxicol Environ Health B Crit Rev. 1998;1:117–34.

    PubMed  CAS  Google Scholar 

  • Hwang BF, Lee YL, Lin YC, Jaakkola JJ, Guo YL. Traffic related air pollution as a determinant of asthma among Taiwanese school children. Thorax. 2005;60:467–73.

    Article  PubMed  Google Scholar 

  • Ichinose T, Yajima Y, Nagashima M, Takeshita S, Nagamachi Y, Sagai M. Lung carcinogenesis and formation of 8-hydroxy-deoxyguanosine in mice by diesel exhaust particles. Carcinogenesis. 1997;18:185–92.

    Article  PubMed  CAS  Google Scholar 

  • Iles KE, Forman HJ. Macrophage signaling and respiratory burst. Immunol Res. 2002;26:95–105.

    Article  PubMed  CAS  Google Scholar 

  • Inoue K-I, Takano H, Yanagisawa R, Sakurai M, Ichinose T, Sadakane K, et al. Effects of nano particles on antigen-related airway inflammation in mice. Respir Res. 2005;6:106.

    Article  PubMed  CAS  Google Scholar 

  • Inoue K-I, Takano H, Yanagisawa R, Hirano S, Sakurai M, Shimada A, et al. Effects of airway exposure to nanoparticles on lung inflammation induced by bacterial endotoxin in mice. Environ Health Perspect. 2006;114:1325–30.

    Article  PubMed  CAS  Google Scholar 

  • Jimenez LA, Thompson J, Brown DA, Rahman I, Antonicelli F, Duffin R, et al. Activation of NF-kappaB by PM10 occurs via an iron-mediated mechanism in the absence of IkappaB degradation. Toxicol Appl Pharmacol. 2000;166:101–10.

    Article  PubMed  CAS  Google Scholar 

  • Johnson AW, Aderele WI. The association of household pollutants and socio-economic risk factors with the short-term outcome of acute lower respiratory infections in hospitalized pre-school Nigerian children. Ann Trop Paediatr. 1992;12:421–32.

    PubMed  CAS  Google Scholar 

  • Kampa M, Castanas E. Human health effects of air pollution. Environ Pollut. 2007;151:362–7.

    Article  PubMed  CAS  Google Scholar 

  • Kan H, Heiss G, Rose KM, Whitsel E, Lurmann F, London SJ. Traffic exposure and lung function in adults: the atherosclerosis risk in communities study. Thorax. 2007;62:873–9.

    Article  PubMed  Google Scholar 

  • Karin M, Liu Z, Zandi E. AP-1 function and regulation. Curr Opin Cell Biol. 1997;9:240–6.

    Article  PubMed  CAS  Google Scholar 

  • Kasprzak KS, Sunderman Jr FW, Salnikow K. Nickel carcinogenesis. Mutat Res. 2003;533:67–97.

    PubMed  CAS  Google Scholar 

  • Kawasaki S, Takizawa H, Takami K, Desaki M, Okazaki H, Kasama T, et al. Benzene-extracted components are important for the major activity of diesel exhaust particles effect on interleukin-8 gene expression in human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2001;24:419–26.

    PubMed  CAS  Google Scholar 

  • Kelsall JE, Samet JM, Zeger SL, Xu J. Air pollution and mortality in Philadelphia, 1974–1988. Am J Epidemiol. 1997;146:750–62.

    PubMed  CAS  Google Scholar 

  • Kennedy T, Ghio AJ, Reed W, Samet J, Zagorski J, Qualy J, et al. Copper-dependent inflammation and nuclear factor-kappaB activation by particulate air pollution. Am J Respir Cell Mol Biol. 1998;19:366–78.

    PubMed  CAS  Google Scholar 

  • Kittelson DB, Watts WF, Johnson JP. Nanoparticle emissions on Minnesota highways. Atmospheric Environ. 2004;38:9–19.

    Article  CAS  Google Scholar 

  • Ko FWS, Tam W, Wong TW, Chan DPS, Tung AH, Lai CKW, et al. Temporal relationship between air pollutants and hospital admissions for chronic obstructive pulmonary disease in Hong Kong. Thorax. 2007a;62:779–84.

    Article  Google Scholar 

  • Ko FWS, Tam W, Wong TW, Lai CKW, Wong GWK, Leung TF, et al. Effects of air pollution on asthma hospitalization rates in different age groups in Hong Kong. Clin Exp Allergy. 2007b;37:1312–9.

    Article  PubMed  CAS  Google Scholar 

  • Kobzik L. Lung macrophage uptake of unopsonized environmental particulates. Role of scavenger-type receptors. J Immunol. 1995;155:367–76.

    PubMed  CAS  Google Scholar 

  • Kopnin PB, Kravchenko IV, Furalyov VA, Pylev LN, Kopnin BP. Cell type-specific effects of asbestos on intracellular ROS levels, DNA oxidation and G1 cell cycle checkpoint. Oncogene. 2004;23:8834–40.

    Article  PubMed  CAS  Google Scholar 

  • Kumagai Y, Arimoto T, Shinyashiki M, Shimojo N, Nakai Y, Yoshikawa T, et al. Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage. Free Radic Biol Med. 1997;22:479–87.

    Article  PubMed  CAS  Google Scholar 

  • Kunii O, Kanagawa S, Yajima I, Hisamatsu Y, Yamamura S, Amagai T, et al. The 1997 haze disaster in Indonesia: its air quality and health effects. Arch Environ Health. 2002;57:16–22.

    Article  PubMed  CAS  Google Scholar 

  • Kwiatkowska K, Sobota A. Signaling pathways in phagocytosis. BioEssays. 1999;21:422–31.

    Article  PubMed  CAS  Google Scholar 

  • Laden F, Hart JE, Smith TJ, Davis ME, Garshick E. Cause-specific mortality in the unionized U.S. trucking industry. Environ Health Perspect. 2007;115:1192–6.

    Article  PubMed  Google Scholar 

  • Laden F, Neas LM, Dockery DW, Schwartz J. Association of fine particulate matter from different sources with daily mortality in six U.S. cities. Environ Health Perspect. 2000;108:941–7.

    Article  PubMed  CAS  Google Scholar 

  • Laden F, Schwartz J, Speizer FE, Dockery DW. Reduction in fine particulate air pollution and mortality. Am J Respir Crit Care Med. 2006;173:667–72.

    Article  PubMed  CAS  Google Scholar 

  • Lagorio S, Forastiere F, Pistelli R, Iavarone I, Michelozzi P, Fano V, et al. Air pollution and lung function among susceptible adult subjects: a panel study. Environ Health. 2006;5:11.

    Article  PubMed  CAS  Google Scholar 

  • Laks D, de Oliveira RC, de Andre PA, Macchione M, Lemos M, Faffe D, et al. Composition of diesel particles influences acute pulmonary toxicity: an experimental study in mice. Inhal Toxicol. 2008;20:1037–42.

    Article  PubMed  CAS  Google Scholar 

  • Lansley AB, Sanderson MJ, Dirksen ER. Control of the beat cycle of respiratory tract cilia by Ca2+ and cAMP. Am J Physiol. 1992;263:L232–42.

    PubMed  CAS  Google Scholar 

  • Lee Y-L, Hsiue T-R, Lee Y-C, Lin Y-C, Guo YL. The association between glutathione S-transferase p1, m1 polymorphisms and asthma in Taiwanese schoolchildren. CHEST. 2005;128:1156–62.

    Article  PubMed  CAS  Google Scholar 

  • Lee SL, Wong WHS, Lau YL. Association between air pollution and asthma admission among children in Hong Kong. Clin Exp Allergy. 2006;36:1138–46.

    Article  PubMed  CAS  Google Scholar 

  • Li XY, Gilmour PS, Donaldson K, MacNee W. In vivo and in vitro proinflammatory effects of particulate air pollution (PM10). Environ Health Perspect. 1997;105:1279–83.

    Article  PubMed  CAS  Google Scholar 

  • Li N, Wang M, Oberley TD, Sempf JM, Nel AE. Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. J Immunol. 2002;169:4531–41.

    PubMed  CAS  Google Scholar 

  • Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, et al. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect. 2003;111:455–60.

    Article  PubMed  CAS  Google Scholar 

  • Li N, Xia T, Nel AE. The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic Biol Med. 2008;44:1689–99.

    Article  PubMed  CAS  Google Scholar 

  • Lin CA, Martins MA, Farhat SC, Pope III CA, Conceição GMS, Anastácio VM, et al. Air pollution and respiratory illness of children in Sao Paulo, Brazil. Paediatr Perinat Epidemiol. 1999;13:475–88.

    Article  PubMed  CAS  Google Scholar 

  • Lin M, Stieb DM, Chen Y. Coarse particulate matter and hospitalization for respiratory infections in children younger than 15 years in Toronto: a case-crossover analysis. Pediatrics. 2005;116:e235–40.

    Article  PubMed  Google Scholar 

  • Logan WPD. Mortality in the London fog incident, 1952. Lancet. 1953;1:336–8.

    Article  PubMed  CAS  Google Scholar 

  • Maki A, Berezesky IK, Fargnoli J, Holbrook NJ, Trump BF. Role of [Ca2+]i in induction of c-fos, c-jun, and c-myc mRNA in rat PTE after oxidative stress. FASEB J. 1992;6:919–24.

    PubMed  CAS  Google Scholar 

  • Mayer AS, Newman LS. Genetic and environmental modulation of chronic obstructive pulmonary disease. Respir Physiol. 2001;128:3–11.

    Article  PubMed  CAS  Google Scholar 

  • Mazzoli-Rocha F, Magalhães CB, Malm O, Saldiva PHN, Zin WA, Faffe DS. Comparative respiratory toxicity of particles produced by traffic and sugar cane burning. Environ Res. 2008;108:35–41.

    Article  PubMed  CAS  Google Scholar 

  • Mccreanor J, Cullinan P, Nieuwenhuijsen MJ, Stewart-Evans J, Malliarou E, Jarup L, et al. Respiratory effects of exposure to diesel traffic in persons with asthma. N Engl J Med. 2007;357:2348–58.

    Article  PubMed  CAS  Google Scholar 

  • Medina-Ramón M, Zanobetti A, Schwartz J. The effect of ozone and PM10 on hospital admissions for pneumonia and chronic obstructive pulmonary disease: a national multicity study. Am J Epidemiol. 2006;163:579–88.

    Article  PubMed  Google Scholar 

  • Melén E, Nyberg F, Lindgren CM, Berglind NB, Zucchelli M, Nordling E, et al. interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Environ Health Perspect. 2008;116:1077–84.

    Article  PubMed  Google Scholar 

  • Michel O, Kips J, Duchateau J, Vertongen F, Robert L, Collet H, et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med. 1996;154:1641–6.

    PubMed  CAS  Google Scholar 

  • Minden A, Karin M. Regulation and function of the JNK subgroup of MAP kinases. Biochimica et Biophysica Acta. 1997;1333:F85–104.

    PubMed  CAS  Google Scholar 

  • Minden A, Lin A, Claret FX, Abo A, Karin M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell. 1995;81:1147–57.

    Article  PubMed  CAS  Google Scholar 

  • Moller W, Brown DM, Kreyling W, Stone V. Ultrafine particles cause cytoskeletal dysfunctions in macrophages: role of intracellular calcium. Part Fibre Toxicol. 2005;2:7.

    Article  PubMed  CAS  Google Scholar 

  • Moller P, Folkmann JK, Forchhammer L, Braüner EV, Danielsen PH, Risom L, et al. Air pollution, oxidative damage to DNA, and carcinogenesis. Cancer Lett. 2008;266:84–97.

    Article  PubMed  CAS  Google Scholar 

  • Mondal K, Haskill JS, Becker S. Adhesion and pollution particle-induced oxidant generation is neither necessary nor sufficient for cytokine induction in human alveolar macrophages. Am J Respir Cell Mol Biol. 2000;22:200–8.

    PubMed  CAS  Google Scholar 

  • Mossman BT, Kamp DW, Weitzman AS. Mechanisms of carcinogenesis and clinical features of asbestos-associated cancers. Cancer Invest. 1996;14:466–80.

    Article  PubMed  CAS  Google Scholar 

  • Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science. 2006;311:622–7.

    Article  PubMed  CAS  Google Scholar 

  • Nemery B, Hoet PHM, Nemmar A. The Meuse Valley fog of 1930: an air pollution disaster. Lancet. 2001;357:704–8.

    Article  PubMed  CAS  Google Scholar 

  • Newton R, Stevens DA, Hart LA, Lindsay M, Adcock IM, Barnes PJ. Superinduction of COX-2 mRNA by cycloheximide and interleukin-1beta involves increased transcription and correlates with increased NF-kappaB and JNK activation. FEBS Lett. 1997;418:135–8.

    Article  PubMed  CAS  Google Scholar 

  • Oberdörster G, Ferin J, Lehnert BE. Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect. 1994;102:173–9.

    Article  PubMed  Google Scholar 

  • Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect. 2005;113:823–39.

    Article  PubMed  CAS  Google Scholar 

  • Oftedal B, Brunekreef B, Nystad W, Madsen C, Walker SE, Nafstad P. Residential outdoor air pollution and lung function in schoolchildren. Epidemiol. 2008;19:129–37.

    Article  Google Scholar 

  • Ohyama M, Otake T, Adachi S, Kobayashi T, Morinaga K. A comparison of the production of reactive oxygen species by suspended particulate matter and diesel exhaust particles with macrophages. Inhal Toxicol. 2007;19:157–60.

    Article  PubMed  CAS  Google Scholar 

  • Overby LH, Nishio S, Weir A, Carver GT, Plopper CG, Philpot RM. Distribution of cytochrome P450 1A1 and NADPH-cytochrome P450 reductase in lungs of rabbits treated with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin: ultrastructural immunolocalization and in situ hybridization. Mol Pharmacol. 1992;41:1039–46.

    PubMed  CAS  Google Scholar 

  • Padmavati S, Joshi B. Incidence and etiology of chronic cor pulmonale in Delhi: a necropsy study. Chest. 1964;46:457–63.

    Article  CAS  Google Scholar 

  • Palecanda A, Paulauskis J, Al-Mutairi E, Imrich A, Qin G, Suzuki H, et al. Role of the scavenger receptor marco in alveolar macrophage binding of unopsonized environmental particles. J Exp Med. 1999;189:1497–506.

    Article  PubMed  CAS  Google Scholar 

  • Park GY, Christman JW. Nuclear factor kappa-B is a promising therapeutic target in inflammatory lung disease. Curr Drug Targets. 2006;7:661–8.

    Article  PubMed  CAS  Google Scholar 

  • Park S, Nam H, Chung N, Park J-D, Lim Y. The role of iron in reactive oxygen species generation from diesel exhaust particles. Toxicol. 2006;20:851–7.

    CAS  Google Scholar 

  • Peel JL, Tolbert PE, Klein M, Metzeger KB, Flanders WD, Todd K, et al. Ambient air pollution and respiratory emergency department visits. Epidemiol. 2005;16:164–74.

    Article  Google Scholar 

  • Peel JL, Metzger KB, Klein M, Flanders D, Mulholland JA, Tolbert PE. Ambient air pollution and cardiovascular emergency department visits in potentially sensitive groups. Am J Epidemiol. 2007;165:625–33.

    Article  PubMed  Google Scholar 

  • Pelclová D, Fenclová Z, Kacer P, Kuzma M, Navrátil T, Lebedová J. Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure. Industrial Health. 2008;46:484–9.

    Article  PubMed  Google Scholar 

  • Pénard-Morand C, Charpinw D, Raherisonz C, Kopferschmittz C, Caillaudk D, Lavaud F, et al. Long-term exposure to background air pollution related to respiratory and allergic health in schoolchildren. Clin Exp Allergy. 2005;35:1279–87.

    Article  PubMed  CAS  Google Scholar 

  • Penttinen P, Timonen KL, Tiittanen P, Mirme A, Ruuskanen J, Pekkanen J. Ultrafine particles in urban air and respiratory health among adult asthmatics. Eur Respir J. 2001;17:428–35.

    Article  PubMed  CAS  Google Scholar 

  • Pereira CEL, Heck TG, Saldiva PHN, Rhoden CR. Ambient particulate air pollution from vehicles promotes lipid peroxidation and inflammatory responses in rat lung. Braz J Med Biol Res. 2007;40:1353–9.

    PubMed  CAS  Google Scholar 

  • Peters A, Wichamann HE, Tuch T, Heinich J, Heyder J. Respiratory effects are associated with the number of ultrafine particles. Am J Respir Crit Care Med. 1997;155:1376–83.

    PubMed  CAS  Google Scholar 

  • Pope III CA. Invited commentary: particulate matter–mortality exposure–response relations and threshold. Am J Epidemiol. 2000;152:407–12.

    Article  PubMed  Google Scholar 

  • Pope III CA, Dockery DW, Schwartz J. Review of epidemiologic evidence of health effects of particulate air pollution. Inhal Toxicol. 1995;7:1–8.

    Article  CAS  Google Scholar 

  • Pope III CA, Burnett RT, Thun MJ, Calle EE, Krewski D, Ito K, et al. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA. 2002;287:1132–41.

    Article  PubMed  CAS  Google Scholar 

  • Pourazar J, Mudway IS, Samet JM, Helleday R, Blomberg A, Wilson SJ, et al. Diesel exhaust activates redox-sensitive transcription factors and kinases in human airways. Am J Physiol, Lung Cell Mol Physiol. 2005;289:L724–30.

    Article  CAS  Google Scholar 

  • Pourazar J, Blomberg A, Kelly FJ, Davies DE, Wilson SJ, Holgate ST, et al. Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium. Part Fibre Toxicol. 2008;5:8.

    PubMed  Google Scholar 

  • Quay JL, Reed W, Samet JM, Devlin RB. Air pollution particles induce IL-6 gene expression in human airway epithelial cells via NF-kappaB activation. Am J Respir Cell Mol Biol. 1998;19:98–106.

    PubMed  CAS  Google Scholar 

  • Rahman I, MacNee W. Role of transcription factors in inflammatory lung diseases. Thorax. 1998;53:601–12.

    Article  PubMed  CAS  Google Scholar 

  • Rahman I, Yang SR, Biswas SK. Current concepts of redox signaling in the lungs. Antioxid Redox Signal. 2006;8:681–9.

    Article  PubMed  CAS  Google Scholar 

  • Regalado J, Pérez-Padilla R, Sandores R, Ramirez JIP, Brauer M, Paré P, et al. The effect of biomass burning on respiratory symptoms and lung function in rural mexican women. Am J Respir Crit Care Med. 2006;174:901–5.

    Article  PubMed  Google Scholar 

  • Reibman J, Hsu Y, Chen LC, Kumar A, Su WC, Choy W, et al. Size fractions of ambient particulate matter induce granulocyte macrophage colony—stimulating factor in human bronchial epithelial cells by mitogen-activated protein kinase pathways. Am J Respir Cell Mol Biol. 2002;27:455–62.

    PubMed  CAS  Google Scholar 

  • Rengasamy A, Barger MW, Kane E, Ma JK, Castranova V, Ma JY. Diesel exhaust particle-induced alterations of pulmonary phase I and phase II enzymes of rats. J Toxicol Environ Health A. 2003;66:153–67.

    Article  PubMed  CAS  Google Scholar 

  • Rinne ST, Rodas EJ, Bender BS, Rinne ML, Simpson JM, Galer-Unti R, et al. Relationship of pulmonary function among women and children to inddor air pollution from biomass use in rural Ecuador. Respir Med. 2006;100:1208–15.

    Article  PubMed  Google Scholar 

  • Risom L, Moller P, Loft S. Oxidative stress-induced DNA damage by particulate air pollution. Mutat Res. 2005;592:119–37.

    PubMed  CAS  Google Scholar 

  • Rizzo MC, Naspitz CK, Fernandez-Caldas E, Lockey RF, Mimica I, Sole D. Endotoxin exposure and symptoms in asthmatic children. Pediatr Allergy Immunol. 1997;8:121–6.

    Article  PubMed  CAS  Google Scholar 

  • Roemer W, Hoek G, Brunekreef B, Clench-Aas J, Forsberg B, Pekkanen J, et al. PM10 elemental composition and acute respiratory health effects in European children (PEACE project). Eur Respir. 2000;15:553–9.

    Article  CAS  Google Scholar 

  • Romieu I, Barraza-Villarreal A, Escamilla-Nuñez C, Almstrand A-C, Diaz-Sanchez D, Sly PD, et al. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma. J Allergy Clin Immunol. 2008;121:903–9.

    Article  PubMed  CAS  Google Scholar 

  • Rouse RL, Murphy G, Boudreaux MJ, Paulsen DB, Penn AL. Soot nanoparticles promote biotransformation, oxidative stress, and inflammation in murine lungs. Am J Respir Cell Mol Biol. 2008;39:198–207.

    Article  PubMed  CAS  Google Scholar 

  • Roveri A, Coassin M, Maiorino M, Zamburlini A, van Amsterdam FT, Ratti E, et al. Effect of hydrogen peroxide on calcium homeostasis in smooth muscle cells. Arch Biochem Biophys. 1992;297:265–70.

    Article  PubMed  CAS  Google Scholar 

  • Ryan PH, LeMasters G, Biagini J, Bernstein D, Grinshpun SA, Shukla R, et al. Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus traffic. J Allergy Clin Immunol. 2005;116:279–84.

    Article  PubMed  Google Scholar 

  • Saatian B, Zhao Y, He D, Georas SN, Watkins T, Spannhake EW, et al. Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells. Biochem J. 2006;393:657–68.

    Article  PubMed  CAS  Google Scholar 

  • Sager TM, Kommineni C, Castranova V. Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area. Part Fibre Toxicol. 2008;5:17.

    Article  PubMed  CAS  Google Scholar 

  • Sakamoto N, Hayashi S, Gosselink J, Ishii H, Ishimatsu Y, Mukae H, et al. Calcium dependent and independent cytokine synthesis by air pollution particle-exposed human bronchial epithelial cells. Toxicol Applied Pharmacol. 2007;225:134–41.

    Article  CAS  Google Scholar 

  • Saldiva PH, Pope III CA, Schwartz J, Dockery DW, Lichtenfels AJ, Salge SM, et al. Air pollution and mortality in elderly people: a time-series study in Sao Paulo, Brazil. Arch Environ Health. 1995;50:159–63.

    Article  PubMed  CAS  Google Scholar 

  • Saldiva PH, Clarke RW, Coull BA, Stearns RC, Lawrence J, Murthy GG, et al. Lung inflammation induced by concentrated ambient air particles is related to particle composition. Am J Respir Crit Care Med. 2002;165:1610–7.

    Article  PubMed  Google Scholar 

  • Schwartz J, Marcus A. Mortality and air pollution in London: a time-series analysis. Am J Epidemiol. 1990;131:185–94.

    PubMed  CAS  Google Scholar 

  • Schwartz J, Dockery DW, Neas LM. Is daily mortality associated specifically with fine particles? J Air Waste Manag Assoc. 1996;46:927–39.

    PubMed  CAS  Google Scholar 

  • Schwartz J, Ballester F, Saez M, Pérez-Hoyos S, Bellido J, Cambra K, et al. The concentration–response relation between air pollution and daily deaths. Environ Health Perspect. 2001;109:1001–6.

    Article  PubMed  CAS  Google Scholar 

  • Seaton A, Macnee W, Donaldson K, Godden D. Particulate air pollution and acute health effects. Lancet. 1995;345:176–8.

    Article  PubMed  CAS  Google Scholar 

  • Shi JP, Evans DE, Khan AA, Harrison RM. Sources and concentration of nanoparticles (<10 nm diameter) in the urban atmosphere. Atmosph Environ. 2001;35:1193–202.

    Article  CAS  Google Scholar 

  • Shukla A, Timblin C, Bérubé K, Gordon T, McKinney M, Driscoll K, et al. Inhaled particulate matter causes expression of nuclear factor (NF)-κB-related genes and oxidant-dependent NF-κB activation in vitro. Am J Respir Cell Mol Biol. 2000;23:182–7.

    PubMed  CAS  Google Scholar 

  • Shukla A, Timblin CR, Hubbard AK, Bravman J, Mossman BT. Silica-induced activation of c-Jun-NH2-terminal amino kinases, protracted expression of the activator protein-1 proto-oncogene, fra-1, and S-phase alterations are mediated via oxidative stress. Cancer Res. 2001;61:1791–5.

    PubMed  CAS  Google Scholar 

  • Singh S, Shi T, Duffin R, Albrecht C, van Berlo D, Höhr D, et al. Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: role of the specific surface area and of surface methylation of the particles. Toxicol Applied Pharmacol. 2007;222:141–51.

    Article  CAS  Google Scholar 

  • Sorensen M, Autrup H, Moller P, Hertel O, Jensen SS, Vinzents P, et al. Linking exposure to environmental pollutants with biological effects. Mutation Res. 2003;544:255–71.

    Article  PubMed  CAS  Google Scholar 

  • Squadrito GL, Cueto R, Dellinger B, Pryor WA. Quinoid redox cycling as a mechanism for sustained free radical generation by inhaled airborne particulate matter. Free Radic Biol Med. 2001;31:1132–8.

    Article  PubMed  CAS  Google Scholar 

  • Stewart RM, Weir EK, Montgomery MR, Niewoehner DE. Hydrogen peroxide contracts airway smooth muscle: a possible endogenous mechanism. Respir Physiol. 1981;45:333–42.

    Article  PubMed  CAS  Google Scholar 

  • Stohs SJ, Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med. 1995;18:321–36.

    Article  PubMed  CAS  Google Scholar 

  • Stohs SJ, Bagci D, Hassoun E, Bagchi M. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J Environ Pathol Toxicol Oncol. 2001;20:77–88.

    PubMed  CAS  Google Scholar 

  • Stone V, Shaw J, Brown DM, MacNee W, Faux SP, Donaldson K. The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function. Toxicol In Vitro. 1998;12:649–59.

    Article  PubMed  CAS  Google Scholar 

  • Stone V, Tuinman M, Vamvakopoulos JE, Shaw J, Brown D, Petterson S, et al. Increased calcium influx in a monocyte cell line on exposure to ultrafine carbon black. Eur Respir J. 2000;15:297–303.

    Article  PubMed  CAS  Google Scholar 

  • Stone V, Johnston H, Clift MJ. Air Pollution, ultrafine and nanoparticle toxicology: cellular and molecular interactions. IEEE Trans Nanobioscience. 2007;6:331–40.

    Article  PubMed  Google Scholar 

  • Suzuki YJ, Ford GD. Superoxide stimulates IP3-induced Ca2+ release from vascular smooth muscle sarcoplasmic reticulum. Am J Physiol Heart Circ Physiol. 1992;262:H114–6.

    CAS  Google Scholar 

  • Suzuki YJ, Ford GD. Inhibition of Ca2+-ATPase of vascular smooth muscle sarcoplasmic reticulum by reactive oxygen intermediates. Am J Physiol Heart Circ Physiol. 1991;261:H568–74.

    CAS  Google Scholar 

  • Takizawa H. Diesel exhaust particles and their effect on induced cytokine expression in human bronchial epithelial cells. Curr Opinion Allergy Clinic Immunol. 2004;4:355–9.

    Article  CAS  Google Scholar 

  • Takizawa H, Ohtoshi T, Kawasaki S, Kohyama T, Desaki M, Kasama T, et al. Diesel exhaust particles induce NF-κB activation in human bronchial epithelial cells in vitro: importance in cytokine transcription1. J Immunol. 1999;162:4705–11.

    PubMed  CAS  Google Scholar 

  • Tao F, Gonzalez-Flecha B, Kobzik L. Reactive oxygen species in pulmonary inflammation by ambient particulates. Free Radic Biol Med. 2003;35:327–40.

    Article  PubMed  CAS  Google Scholar 

  • Tapon N, Nagata K, Lamarche N, Hall A. A new rac target POSH is an SH3-containing scaffold protein involved in the JNK/MAPK and NF-kappaB signaling pathways. EMBO J. 1998;17:1395–404.

    Article  PubMed  CAS  Google Scholar 

  • Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol, Lung Cell Mol Physiol. 2000;279:L1005–28.

    CAS  Google Scholar 

  • Thorne PS, Kulhankova K, Yin M, Cohn R, Arbes Jr SJ, Zeldin DC. Endotoxin exposure is a risk factor for asthma: the national survey of endotoxin in United States housing. Am J Respir Crit Care Med. 2005;172:1371–7.

    Article  PubMed  Google Scholar 

  • Timblin CR, Janssen YWM, Mossman BT. Transcriptional activation of the proto-oncogene c-jun, by asbestos and H2O2, is directly related to increased proliferation and transformation of tracheal epithelial cells. Cancer Res. 1995;55:2723–6.

    PubMed  CAS  Google Scholar 

  • Timblin C, BeruBe K, Churg A, Driscoll K, Gordon T, Hemenway D, et al. Ambient particulate matter causes activation of the c-jun kinase/stress-activated protein kinase cascade and DNA synthesis in lung epithelial cells. Cancer Res. 1998;58:4543–7.

    PubMed  CAS  Google Scholar 

  • Timblin CR, Shukla A, Berlanger I, Berube KA, Churg A, Mossman BT. Ultrafine airborne particles cause increases in protooncogenese expression and proliferation in alveolar epithelial cells. Toxicol Appl Pharmacol. 2002;179:98–104.

    Article  PubMed  CAS  Google Scholar 

  • Tkaczyk J, Vízek M. Oxidative stress in the lung tissue—sources of reactive oxygen species and antioxidant defence. Prague Medical Report. 2007;108:105–14.

    PubMed  CAS  Google Scholar 

  • Tokiwa H, Sera N, Nakanishi Y, Sagai M. 8-Hydroxyguanosine formed in human lung tissue and the association with diesel exhaust particles. Free Radic Biol Med. 1999;27:1251–8.

    Article  PubMed  CAS  Google Scholar 

  • Tuntawiroon J, Mahidol C, Navasumrit P, Autrup H, Ruchirawat M. Increased health risk in Bangkok children exposed to polycyclic aromatic hydrocarbons from traffic-related sources. Carcinogenesis. 2007;28:816–22.

    Article  PubMed  CAS  Google Scholar 

  • US EPA, United States Environmental Protective Agency. Mobile source air toxics: control of hazardous air pollutants from mobile sources 2005; http://www.epa.gov/otaq/regs/toxics/420r05901.pdf.

  • Utell MJ, Frampton MW. Acute health effects of ambient air pollution: the ultrafine particle hypothesis. J Aerosol Med. 2000;13:355–9.

    Article  PubMed  CAS  Google Scholar 

  • Valença SS, Castro P, Pimenta WA, Lanzetti M, Silva SV, Barja-Fidalgo C, et al. Light cigarette smoke-induced emphysema and NF-κB activation in mouse lung. Int J Exp Pathol. 2006;87:373–81.

    Article  PubMed  CAS  Google Scholar 

  • Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem. 2005;12:1161–208.

    Article  PubMed  CAS  Google Scholar 

  • Vanden Berghe W, Plaisance S, Boone E, De Bosscher K, Schmitz ML, Fiers W, et al. P38 and extracellular signal regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor. J Biol Chem. 1998;273:3285–90.

    Article  Google Scholar 

  • Veronesi B, Oortgiesen M, Carter JD, Devlin RB. Particulate matter initiates inflammatory cytokine release by activation of capsaicin and acid receptors in a human bronchial epithelial cell line. Toxicol Appl Pharmacol. 1999;154:106–15.

    Article  PubMed  CAS  Google Scholar 

  • Veronesi B, De Haar C, Roy J, Oortgiesen M. Particulate matter inflammation and receptor sensitivity are target cell specific. Inhal Toxicol. 2002;14:159–83.

    Article  PubMed  CAS  Google Scholar 

  • Wang S, Chanock S, Tang D, Li Z, Jedrychowski W, Perera FP. Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns. Cancer Epidemiol Biomarkers Prev. 2008;17:405–13.

    Article  PubMed  CAS  Google Scholar 

  • Wegesser TC, Last JA. Mouse lung inflammation after instillation of particulate matter collected from a working dairy barn. Toxicol Appl Pharmacol. 2009;236:348–57.

    Article  PubMed  CAS  Google Scholar 

  • Weichenthal S, Dufresne A, Infante-Rivard C. Indoor ultrafine particles and childhood asthma: exploring a potential public health concern. Indoor Air. 2007;17:81–91.

    Article  PubMed  CAS  Google Scholar 

  • Wilson M, Lightbody JH, Donaldson K, Sales JH, Stone V. Interactions between ultrafine particles and transition metals in vivo and in vitro. Toxicol Appl Pharmacol. 2002;184:172–9.

    Article  PubMed  CAS  Google Scholar 

  • Wu W, Graves LM, Jaspers I, Devlin RB, Reed W, Samet JM. Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals. Am J Physiol. 1999;277:L924–31.

    PubMed  CAS  Google Scholar 

  • Wu W, Jaspers I, Zhang W, Graves LM, Samet JM. Role of Ras in metal-induced EGF receptor signaling and NFkappaB activation in human airway epithelial cells. Am J Physiol, Lung Cell Mol Physiol. 2002;282:L1040–8.

    CAS  Google Scholar 

  • Xia T, Kovochich M, Nel A. The role of reactive oxygen species and oxidative stress in mediating particulate matter injury. Clin Occup Environ Med. 2006;5:817–36.

    PubMed  Google Scholar 

  • Zanobetti A, Schwartz J, Dockery DW. Airborne particles are a risk factor for hospital admissions for heart and lung disease. Environ Health Perspect. 2000;108:1071–7.

    Article  PubMed  CAS  Google Scholar 

  • Zhang JJ, Smith KR. Household air pollution from coal and biomass fuels in China: measurements, health impacts and interventions. Environ Health Perspect. 2007;115:848–55.

    Article  PubMed  Google Scholar 

  • Zhao H, Barger MW, Ma JKH, Castranova V, Ma JYC. Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles. Environ Health Perspect. 2006;114:1253–8.

    Article  PubMed  CAS  Google Scholar 

  • Zhao H, Ma JK, Barger MW, Mercer RR, Millecchia L, Schwegler-Berry D, et al. Reactive oxygen species- and nitric oxide-mediated lung inflammation and mitochondrial dysfunction in wild-type and iNOS-deficient mice exposed to diesel exhaust particles. J Toxicol Environ Health A. 2009a;72:560–70.

    Article  PubMed  CAS  Google Scholar 

  • Zhao J, Shi X, Castranova V, Ding M. Occupational toxicology of nickel and nickel compounds. J Environ Pathol Toxicol Oncol. 2009b;28:177–208.

    PubMed  Google Scholar 

  • Zhong CY, Zhou YM, Douglas GC, Witschi H, Pinkerton KE. MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of rats. Carcinogenesis. 2005;26:2187–95.

    Article  PubMed  CAS  Google Scholar 

  • Zhong CY, Zhou YM, Joad JP, Pinkerton KE. Environmental tobacco smoke suppresses nuclear factor-κB signaling to increase apoptosis in infant monkey lungs. Am J Respir Crit Care Med. 2006;174:428–36.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratório de Fisiologia da Respiração, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

    Flavia Mazzoli-Rocha, Silviane Fernandes & Walter Araújo Zin

  2. Laboratório de Físico-Química Biológica Aída Hassón-Voloch, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

    Marcelo Einicker-Lamas

  3. Instituto de Biofísica Carlos Chagas Filho, C.C.S., Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, Ilha do Fundão, 21941-902, Rio de Janeiro, Rio de Janeiro, Brazil

    Walter Araújo Zin

Authors
  1. Flavia Mazzoli-Rocha
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  2. Silviane Fernandes
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  3. Marcelo Einicker-Lamas
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  4. Walter Araújo Zin
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Corresponding author

Correspondence to Walter Araújo Zin.

Additional information

This study was supported by the Brazilian Council for Scientific and Technological Development (CNPq), Carlos Chagas Filho Rio de Janeiro State Research Supporting Foundation (FAPERJ), and the Ministry of Science and Technology (MCT).

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Mazzoli-Rocha, F., Fernandes, S., Einicker-Lamas, M. et al. Roles of oxidative stress in signaling and inflammation induced by particulate matter. Cell Biol Toxicol 26, 481–498 (2010). https://doi.org/10.1007/s10565-010-9158-2

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  • DOI: https://doi.org/10.1007/s10565-010-9158-2

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