Early identification of amyloid heart disease by technetium-99m-pyrophosphate scintigraphy: A study with familial amyloid polyneuropathy☆
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Cited by (45)
Radionuclide Imaging of Cardiac Amyloidosis
2021, PET ClinicsCitation Excerpt :They found significantly greater extent of microcalcifications in cases of ATTR compared with AL, whereas macrophage expression was significantly lower in ATTR than AL,19 indicating that the increased level of microcalcifications, and not macrophage expression, may explain the enhanced affinity of bone-seeking probes for ATTR over AL amyloidosis, as described later. 99mTc-PYP is an ATTR-specific single-photon emitter tracer that readily identifies ATTR cardiac amyloidosis.20 In a single-center, blinded, prospective cohort study, 45 subjects (12 AL, 16 wild-type ATTR, and 17 mutant ATTR) underwent 99mTc-PYP scintigraphy cardiac imaging and were scored based on cardiac retention of the tracer; subjects with ATTR cardiac amyloid had a significantly higher cardiac retention scores: visual and quantitative (heart–to–contralateral uptake ratio).
Prevalence of wild type ATTR assessed as myocardial uptake in bone scan in the elderly population
2018, International Journal of CardiologyCitation Excerpt :In addition, a large proportion of individuals was receiving diuretics and had elevated concentrations of natriuretic peptides. These results support the view that TTR deposition is a continuous process and that the cardiac uptake of bone tracers precedes clinical manifestations of HF, allowing the early diagnosis of TTR cardiac amyloidosis even before the appearance of other echocardiographic and electrocardiographic abnormalities or overt clinical manifestations [10, 18–20]. The present study has some limitations, mainly derived from its retrospective nature.
Lung uptake during 99mTc-hydroxymethylene diphosphonate scintigraphy in patient with TTR cardiac amyloidosis: An underestimated phenomenon
2018, International Journal of CardiologyCitation Excerpt :Amyloidoses are rare diseases characterized by extracellular deposition of protein-derived fibrils which show apple-green birefringence when stained with Congo red and viewed under polarized light in various tissues and organs, including the heart [1]. Full body scintigraphy using bone tracers plays an important role in defining the type of amyloidosis and in diagnosing the heart involvement (cardiac amyloidosis, CA) [2–10]. Pathologically, involvement in the amyloid deposition of the respiratory tract is common [11–14] and may involve the lungs in 4 distinct forms: lymphatic, diffuse alveolar septal, nodular parenchymal, and tracheobronchial, with the former two patterns commonly present in patients with systemic involvement and the latter two occurring more commonly in localized forms.
Bone scintigraphy for cardiac amyloidosis imaging: Past, present and future
2017, Medecine NucleaireCitation Excerpt :Despite few cases reporting soft-tissue 99mTc- methylene-diphosphonate (MDP) uptake in systemic amyloidosis [36] and myocardial 99mTc-MDP uptake in wt-TTR-related amyloidosis [37,38], and despite one study suggesting better contrast than 99mTc-PYP [26] possibly explained by different biological characteristics [39], this tracer was quickly abandoned because of its lower diagnostic performance in demonstrating amyloid deposits within the heart [33,40]. 99mTc-PYP [17,19,24–30,41] and 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) [31–33,42–44] are nowadays the most widely bone tracer studied for TTR-related CA imaging. However, few case had reported hydroxymethylene-diphosphonate (HMDP) uptake in CA [45] and a recent multicenter study over 1200 patients has shown that HMDP can be used with the same proprieties than others tracers [34].
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Supported in part by grants from the Ministry of Health and Welfare Primary Amloidosis Research Committee, Japan.