Severity of coronary artery disease in young patients with insulin-dependent diabetes mellitus
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Cited by (72)
Association of Diabetes Mellitus and Its Types with In-Hospital Management and Outcomes of Patients with Acute Myocardial Infarction
2023, Cardiovascular Revascularization MedicineCoronary Artery Calcium Dispersion and Cause-Specific Mortality
2023, American Journal of CardiologyDifferential Impact of Type 1 and Type 2 Diabetes Mellitus on Outcomes Among 1.4 Million US Patients Undergoing Percutaneous Coronary Intervention
2022, Cardiovascular Revascularization MedicineIntensive Diabetes Treatment and Cardiovascular Outcomes in Type 1 Diabetes Mellitus: Implications of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study 30-Year Follow-up
2018, Endocrinology and Metabolism Clinics of North AmericaCitation Excerpt :Data on atherosclerotic lesion morphology in humans are sparse. Individuals with T1D show evidence of multivessel disease, increased plaque burden, and severe stenotic and distal lesions compared with patients without diabetes.23 Small postmortem studies have revealed soft, fibrous, and concentric lesions with increased T-cell and macrophage infiltration in individuals with T1D compared with those without.24
MCP-1and IL-1β expression in the myocardia of two young patients with Type 1 diabetes mellitus and fatal diabetic ketoacidosis
2014, Experimental and Molecular PathologyCitation Excerpt :Left ventricular diastolic dysfunction also occurs with insulin resistance (IR), a prediabetic stage of T2DM (Mizushige et al., 2000), and preclinical DC in middle-aged adults with T2DM is common (Kiencke et al., 2010). A predisposition to the early development of CAD is also known to occur in young patients with T1DM (Gunczler et al., 2006; Valsania et al., 1991) and with IR/metabolic syndrome (MetS) (Tirosh et al., 2011). Both forms of insulin dysregulation can lead to cardiovascular disease and heart failure (Kiencke et al., 2010), a leading cause of diabetes related morbidity and mortality, and a major clinical and public health challenge (Hoerger and Ahmann, 2008).
A new score for risk stratification of patients with acute coronary syndromes undergoing percutaneous coronary intervention: The ACUITY-PCI (Acute Catheterization and Urgent Intervention Triage Strategy-Percutaneous Coronary Intervention) risk score
2012, JACC: Cardiovascular InterventionsCitation Excerpt :The clinical variables incorporated in the ACUITY-PCI score were insulin-treated diabetes and renal insufficiency. Patients with diabetes and renal insufficiency have more extensive and complex coronary artery disease, which is often deemed responsible for the adverse prognosis of these patients (16–18). It is noteworthy that in our analysis, insulin-treated diabetes and renal insufficiency were not significantly correlated with the angiographic factors that were retained in the prognostic ACUITY-PCI score.