Symposium on coronary care unit
Cardiovascular and pulmonary changes in patients with myocardial infarction treated in an intensive care and research unit

https://doi.org/10.1016/0002-9149(67)90026-4Get rights and content

Abstract

These observations show that acute myocardial infarction not only damages the left ventricle with subsequent failure of cardiac output but also may have profound effects on such organs as the lungs, kidneys, brain, endocrines and acid-base metabolism as well as reflex effects on the circulation by way of the autonomic nervous system.

At present, many of these mechanisms are not completely understood, and further research is necessary to give a clearer appreciation of why the patient is ill.

Cited by (19)

  • A randomised controlled trial of the effect of high concentration oxygen on myocardial ischaemia during exercise

    2012, International Journal of Cardiology
    Citation Excerpt :

    However, there is also substantive evidence to suggest that high concentration oxygen therapy may be harmful when administered to patients with myocardial ischaemia who are not hypoxaemic [7]. Specifically, high concentration oxygen treatment increases coronary vascular resistance and reduces coronary blood flow [3,8–11], increases systemic vascular resistance and blood pressure, and reduces cardiac output [12–19]. The magnitude of these physiological responses may be substantial, as illustrated by a recent systematic review and meta-analysis which reported that high concentration oxygen reduces coronary blood flow by 8 to 29% and increases coronary vascular resistance by 22% to 41% [11].

View all citing articles on Scopus

From the Medical Research Council Cardiovascular Research Unit, Postgraduate Medical School, Hammersmith Hospital, London, W.12, England.

View full text