Clinical study“Malignant” hypertrophic cardiomyopathy: Identification of a subgroup of families with unusually frequent premature death
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Evolution of risk stratification and sudden death prevention in hypertrophic cardiomyopathy: Twenty years with the implantable cardioverter-defibrillator
2021, Heart RhythmCitation Excerpt :Several primary risk markers have been advanced over the years to identify patients at highest risk for SD.1,4–16,19–21,50–54 The evolving risk algorithm began with asymptomatic bursts of nonsustained ventricular tachycardia (NSVT) on ambulatory electrocardiography (ECG)50,52,S-8 and thereafter family history of SD based on pedigrees with clustered malignant events.55 Ultimately, cardiovascular magnetic resonance (CMR) and other markers were added,16,41,43–45 but abnormal blood pressure response to exercise is judged weak and has fallen out of favor.4,16,
Sudden Cardiac Death and Ventricular Arrhythmias in Hypertrophic Cardiomyopathy
2019, Heart Lung and CirculationCitation Excerpt :Although there is some heterogeneity in the definition of “significant family history” in the literature, (ranging from one affected family member under 50 years of age to at least two first degree relatives [24,25]), current guidelines have accepted any affected first degree relative to be sufficient. Risk almost certainly increases if multiple family members have suffered SCD or resuscitated cardiac arrest, particularly at a younger age [26]. Unexplained syncope was found to increase the risk of sudden death in a retrospective multicentre study of 1,511 patients [27].
A Family History of Sudden Death Should Not Be a Primary Indication for an Implantable Cardioverter Defibrillator in Hypertrophic Cardiomyopathy
2015, Canadian Journal of CardiologyAdvances in medical treatment of hypertrophic cardiomyopathy
2014, Journal of CardiologyCitation Excerpt :Maron et al. identified two clinical variables as reliable markers for identifying the subgroup of patients with HCM who were at increased risk for sudden death. First, a familial history of sudden premature death may constitute a risk factor in certain families with unusually virulent expressions of HCM [14]. Second, 24-h ambulatory electrocardiographic monitoring may be useful in identifying certain patients with HCM who are at increased risk for sudden death [15].
Management of hypertrophic cardiomyopathy
2014, Annals of Global HealthCitation Excerpt :A family history of HCM-related SCD is associated with an increased risk for death in affected family members. The risk is particularly high if there are multiple SCD events in one family and if the events occur at a young age.65,66 Syncope, if not attributable to another cause, is a risk factor for SCD in patients with HCM.67
Epidemiology of Sudden Cardiac Death in Patients with Heart Failure
2011, Heart Failure Clinics