MiscellaneousCardiac myocytes and dendritic cells harbor human immunodeficiency virus in infected patients with and without cardiac dysfunction: Detection by multiplex, nested, polymerase chain reaction in individually microdissected cells from right ventricular endomyocardial biopsy tissue☆
References (30)
- et al.
Emerging patterns of heart disease in human immunodeficiency virus infection
Hum Pathol
(1990) - et al.
Infection of the heart by the human immunodeficiency virus
Am J Cardiol
(1990) - et al.
Identification of human immunodeficiency virus-1 RNA and DNA in the heart of a child with cardiovascular abnormalities and congenital acquired immune deficiency syndrome
Am J Cardiol
(1990) - et al.
Importance of the endpoint noise reduction in analysis of the signal-averaged electrocardiogram
Am J Cardiol
(1989) - et al.
Detection of HIV1 DNA in infants and children by means of the polymerase chain reaction
Lancet
(1988) - et al.
Induction of major histocompatibility complex antigens within the myocardium of patients with active myocarditis: a nonhistologic marker of myocarditis
J Am Coll Cardiol
(1990) - et al.
Myocardial dysfunction in sepsis
Chest
(1989) - et al.
TNF-Induced cardiomyopathy
Lancet
(1990) - et al.
Congestive cardiomyopathy and illness related to the acquired immunodeficiency syndrome (AIDS) associated with isolation of retrovirus from myocardium
Ann Intern Med
(1987) - et al.
Human immunodeficiency virus, coxsackievirus, and cardiomyopathy
Ann Intern Med
(1988)
Proliferative membranopathy and human immunodeficiency virus in AIDS hearts
J Acquir Immune Defic Syndr
Analysis of human immunodeficiency virus and cytomeg alovirus infection by polymerase chain reaction in the acquired immunodeficiency syndrome. An autopsy study
Arch Pathol Lab Med
Use of signals in the terminal QRS complex to identify patients with ventricular tachycardia after myocardial infarction
Circulation
Specific synthesis of DNA in vitro via a polymerasecatalyzed chain reaction
Cited by (71)
HIV-Associated Cardiovascular Disease: Role of Connexin 43
2017, American Journal of PathologyCitation Excerpt :Several laboratories using different models have demonstrated that HIV infection in combination with systemic inflammation and ART cytotoxicity results in cardiac pathologic processes.47–49 Furthermore, in the past couple of years, there is increasing clinical and experimental evidence that HIV infects cardiomyocytes in vitro and in vivo.50–52 Furthermore, it was reported that gp120 interaction with CXCR4 on the surface of cardiomyocytes triggers caspase-dependent mitochondrial activation and apoptosis.53
HIV-1 gp120 induces autophagy in cardiomyocytes via the NMDA receptor
2013, International Journal of CardiologyCitation Excerpt :Cardiovascular abnormalities may directly result from the human immunodeficiency virus type 1 (HIV-1) infection of cardiomyocytes or the effects of HIV-1 encoded proteins which disturb the normal cellular biological process. Cardiovascular abnormalities may also be indirectly induced by the effects of cytokines, co-infection with bacteria, autoimmunity caused by HIV infection, as well as antiretroviral toxicity [4–8]. Among HIV-1 encoded proteins, the HIV-1 envelope glycoprotein gp120 (gp120) has been extensively studied for its pathogenic roles in HIV-1 induced cardiovascular abnormalities.
Soluble mediators of inflammation in HIV and their implications for therapeutics and vaccine development
2012, Cytokine and Growth Factor ReviewsCitation Excerpt :Hypotheses for this increase were attributed to viral or opportunistic co-infections [72,73], autoimmune responses to cardiac proteins, or drug related toxicity [74]. The etiology of cardiac disease in AIDS patients is unclear; however, HIV gene transcripts have been identified in cardiac tissues and in vitro studies have shown that HIV-1 can infect cardiac myocytes [75]. Although it was hypothesized that HIV-infection itself could cause cardiac pathology, in vitro infection studies have shown that although HIV-1 infects cardiomyocytes, this infection does not yield new HIV-1 virions and therefore may not be the direct cause of pathology [76].
Detection of Maedi-Visna Virus in the Liver and Heart of Naturally Infected Sheep
2007, Journal of Comparative PathologyLongitudinal analysis of monocyte/macrophage infection in simian immunodeficiency virus-infected, CD8<sup>+</sup> T-cell-depleted macaques that develop lentiviral encephalitis
2006, American Journal of PathologyCitation Excerpt :The lineage of the non-double-labeled cells is unknown. Although we favor the interpretation that these infected cells are unlabeled macrophages or lymphocytes, other tissue cells (eg, astrocytes) have been proposed to be infected.81–88 Within the CNS of these macaques, we have been unable to co-localize SIV antigen with neuroglial markers.
Cardiomyopathies
2006, Nadas' Pediatric Cardiology
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This work was supported in part by Grants HL41507 and CA47994 from the National Institutes of Health, Bethesda, Maryland.
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Dr. Hsia is the recipient of a Pfizer Scholar's Award.