Elsevier

Thrombosis Research

Volume 48, Issue 5, 1 December 1987, Pages 591-596
Thrombosis Research

Brief communication
The effect of molecular weight on the bioavailability of heparin

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    Therefore, heparin and its derivatives are widely used in the prevention and treatment of thrombosis. However, UFH has low bioavailability (Emanuele & Fareed, 1987) and can cause some serious adverse drug reaction such as heparin-induced thrombocytopenia (HIT) (Warkentin et al., 1995) and a risk of bleeding (Da Silva & Sobel, 2002). The depolymerization of heparin produces smaller molecules (LMWH and ULMWH) that have a better bioavailability and a lower risk of adverse drug reaction.

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    Solutol® HS 15 has been demonstrated to increase coenzyme Q10 bioavailability five-fold with Witepsol H35 and Lauroglycol FCC (Nepal et al., 2010). Both the Labrasol and GTCC (medium chain triglycerides) have been confirmed to significantly increase the bioavailability of heparin (Emanuele and Fareed, 1987; Hoffart et al., 2006), insulin (Eaimtrakarn et al., 2002; Watnasirichaikul et al., 2002), and other hydrophilic macromolecules. In our study, the great ability to resist pepsin and trypsin degradation of rhPTH1-34 was confirmed by the in vitro study for microemulsion.

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