Brief communicationThe effect of molecular weight on the bioavailability of heparin
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Evaluation of the anticoagulant potential of polysaccharide-rich fractions extracted from macroalgae
2017, Natural Product ResearchUltrasonic-assisted preparation of a low molecular weight heparin (LMWH) with anticoagulant activity
2013, Carbohydrate PolymersCitation Excerpt :Therefore, heparin and its derivatives are widely used in the prevention and treatment of thrombosis. However, UFH has low bioavailability (Emanuele & Fareed, 1987) and can cause some serious adverse drug reaction such as heparin-induced thrombocytopenia (HIT) (Warkentin et al., 1995) and a risk of bleeding (Da Silva & Sobel, 2002). The depolymerization of heparin produces smaller molecules (LMWH and ULMWH) that have a better bioavailability and a lower risk of adverse drug reaction.
Preliminary evaluation of a novel oral delivery system for rhPTH1-34: In vitro and in vivo
2011, International Journal of PharmaceuticsCitation Excerpt :Solutol® HS 15 has been demonstrated to increase coenzyme Q10 bioavailability five-fold with Witepsol H35 and Lauroglycol FCC (Nepal et al., 2010). Both the Labrasol and GTCC (medium chain triglycerides) have been confirmed to significantly increase the bioavailability of heparin (Emanuele and Fareed, 1987; Hoffart et al., 2006), insulin (Eaimtrakarn et al., 2002; Watnasirichaikul et al., 2002), and other hydrophilic macromolecules. In our study, the great ability to resist pepsin and trypsin degradation of rhPTH1-34 was confirmed by the in vitro study for microemulsion.
Heparin and low molecular weight heparin in thrombosis and inflammation. emerging links
2005, Chemistry and Biology of Heparin and Heparan Sulfate