Original studyPrognostic indicators of chronic chagasic cardiopathy☆
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Cited by (44)
Biomarkers and Mortality in Severe Chagas Cardiomyopathy
2015, Global HeartEtiological treatment of Chagas disease patients with benznidazole lead to a sustained pro-inflammatory profile counterbalanced by modulatory events
2015, ImmunobiologyCitation Excerpt :A major observation from the analysis of the cardiac group after Bz-therapy was that the overall complexity of the networks, as determined by the number of significant interactions, was similar to that observed in IND before treatment. These findings further support the hypothesis that there is a fine-tuning between all the mediators with major relevance to prevent the clinical progression of heart disease, as reported in other studies (Viotti et al. 2004; Viotti et al. 2004, 2006; Espinosa et al. 1991; Bestetti et al. 1994). In this context, Bz treatment not only may interrupt parasite replication but also induce new regulatory mechanisms, thus triggering a different host immune response (Laucella et al. 2009).
The prognostic significance of electrocardiographic changes in Chagas disease
2012, Journal of ElectrocardiologyCitation Excerpt :The presence of complex ventricular arrhythmias, a peculiarity of this cardiomyopathy, translates into increased risk of sudden death and is a significant determining prognostic factor for survival.3,5,7 Echocardiography is an essential complementary method for evaluating ChCM, making it possible to determine the state of progress and the seriousness of the cardiac impairment, giving an estimate of the degree of left ventricle (LV) dysfunction and hence supplying fundamental data to guide therapy and prognosis.3,4,8-11 Standing out among the evaluated parameters are the presence of global systolic ventricular dysfunction of the LV measured by the left ventricular ejection fraction (LVEF), the occurrence of segment abnormalities, the presence of LV apical aneurysms, and an increase in the size and dysfunction of the right ventricle.3,12
Mortality indicators among chronic Chagas patients living in an endemic area
2010, International Journal of CardiologyCitation Excerpt :Through this, adequate planning for measures to control the disease can be established. Several studies have attempted to determine which factors relating to chronic Chagas disease patients might serve as prognostic factors for the evolution of this disease [5,10–12,15–17]. Our study showed that eight variables were proven to be independent prognostic factors for mortality, in relation to the three types of death analysed.
Predictors of mortality in patients with dilated cardiomyopathy: Relevance of chagas disease as an etiological factor
2010, Revista Espanola de Cardiologia
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This study was financed by the National Medicine Academy, Caracas, Venezuela.