Regular paperReduced cardiovascular responsiveness to exercise-induced sympathoadrenergic stimulation in patients with cirrhosis
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Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction
2021, JACC: Basic to Translational ScienceCitation Excerpt :The exact mechanism of the increased cardiac output in cirrhosis at rest is not well understood, but it may be related to reduced central and arterial blood volume in patients with cirrhosis (74), which would lead to deactivation of arterial baroreceptors and an increase in the activity of the sympathetic nervous system and thus an increase in heart rate and cardiac output. The reduced cardiac performance in cirrhosis during stress may relate to blunted heart rate response, reduced myocardial contractility, and significant wasting of skeletal muscles (74,76-78). Furthermore, cirrhosis is associated with dysfunctional plasma membrane and ion channels, which predisposes patients with cirrhosis to conduction abnormalities and arrhythmias, which can further exacerbate cardiac dysfunction (74).
Myocardial Dysfunction in Cirrhotic Cardiomyopathy is Associated with Alterations of Phospholamban Phosphorylation and IL-6 Levels
2021, Archives of Medical ResearchAssociation between cardiac dysfunction, arrhythmias and chronic liver diseases: A narrative review
2020, Trends in Anaesthesia and Critical CareAssociation of Autoimmune Hepatitis and Cardiovascular Disease
2019, Digestive and Liver DiseaseCitation Excerpt :Lastly, after review of this work, it appears that a clinical entity is similar to the scenario described above. Cirrhotic cardiomyopathy is characterized by cardiac dysfunction [46–49] due to systemic and splanchnic vasodilatation in advancing cirrhosis [50]. Analyses showed a correlation between severity of liver decompensation and cardiac disease [51], with increased inflammation thought to be involved in the latter process [50].
EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis
2018, Journal of Hepatology