Trends in Genetics
Volume 12, Issue 11, November 1996, Pages 472-478
Journal home page for Trends in Genetics

Review
Directing alternative splicing: cast and scenarios

https://doi.org/10.1016/0168-9525(96)10037-8Get rights and content

Abstract

Recent progress in the study of alternative RNA splicing indicates that the interaction of RNA-binding proteins with specific target elements modulates splice site recognition and spliceosome assembly. The identity of splicing signals, the presence of modulating elements and differences in the distribution of RNA-binding proteins are key determinants involved in the tissue-specific regulation of splice site selection.

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      Diabetic conditions dramatically affect gene expression and AS contributing to disease pathogenesis [10,11], but there is limited information on AS regulators responsible for such changes [11,12]. AS allows selective inclusion or exclusion of alternative exons, introns, or parts of exons and introns into the mature mRNA; thereby controlling gene expression and generating different protein isoforms [13–15]. Precise regulation of AS is critical for heart function and development [16,17].

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