Original contributionPotentiation of cocaine toxicity with calcium channel blockers
References (36)
- et al.
Management of cocaine poisoning
Ann Emerg Med
(1983) - et al.
Propranolol-induced hypertension in treatment of cocaine intoxication
Ann Emerg Med
(1985) - et al.
Effect of various calcium channel blockers on three different models of limbic seizures in rats
Neuropharmacology
(1988) - et al.
Cocaine modulation of central monoaminergic neurotransmission
Pharmacol Biochem Behav
(1987) - et al.
Cardiovascular effects of cocaine in anesthetized and conscious rats
Life Sci
(1987) - et al.
Cathinone, cocaine and methamphetamine: Similarity of behavioral effects
Pharmacol Biochem Behav
(1985) - et al.
Effects of cocaine on several adrenergic system parameters
Gen Pharmacol
(1985) - et al.
Management of the cocaine-intoxicated patient
Ann Emerg Med
(1987) - et al.
Amitriptyline provides long-lasting immunization against sudden cardiac death from cocaine
Eur J Pharmacol
(1981) Calcium channel blockers in emergency medicine
Ann Emerg Med
(1984)
The ontogeny of specific binding sites for the calcium channel antagonist, nitrendipine, in mouse heart and brain
Brain Res
Selective central nervous system calcium channel blockers—A new class of anticonvulsant agents
Nifedipine: More than a calcium channel blocker
Gen Pharmacol
Medical risks of cocaine use
West J Med
Medical complications of cocaine abuse
N Engl J Med
Cocaine and other stimulants
N Engl J Med
Antidotes for cocaine poisoning
N Engl J Med
A calcium-channel blocker as antidote to the cardiac effects of cocaine intoxication
N Engl J Med
Cited by (49)
Analysis of cocaine adulterants in human brain in cases of drug-related death
2018, Forensic Science InternationalCitation Excerpt :It was suggested that the protective effects of calcium channel blockers against the cardiac toxicity might be the reason for adding them. Contrary to these assumptions, Derlet and Albertson [9] showed that diltiazem also potentiates COC toxicity. Local anesthetics induce the effect of oral numbness of COC and lead consumers to assume high quality when they taste the drug [3,4].
Drug-related death: Adulterants from cocaine preparations in lung tissue and blood
2015, Forensic Science InternationalCitation Excerpt :According to a study by Derlet and Albertson, exactly the opposite seems to be the true. They found out that the toxic effects of cocaine were potentiated at specific doses of diltiazem [12] and that no protective effect was observed [13]. In the present study, diltiazem was detected in three cases (Fig. 5).
Analysis of cocaine and its adulterants in drugs for international trafficking seized by the Brazilian Federal Police
2015, Forensic Science InternationalRethinking cocaine-associated chest pain and acute coronary syndromes
2011, Mayo Clinic ProceedingsEvaluation and management of the patient who has cocaine-associated chest pain
2006, Cardiology ClinicsCocaine-associated chest pain
2005, Emergency Medicine Clinics of North AmericaCitation Excerpt :In rats, nitrendipine has been shown to prevent cardiac toxicity caused by IV cocaine administration [118,119]. In another study in which rats were pretreated with diltiazem, nifedipine, or verapamil and then subjected to high doses of intraperitoneal cocaine, pretreatment with calcium channel blockers resulted in the development of seizures more quickly in pretreated animals than in controls, indicating that calcium channel blockers may actually potentiate cocaine-induced toxicity [120]. Although verapamil has been demonstrated to alleviate cocaine-induced coronary vasoconstriction in patients undergoing cardiac catheterization for the evaluation of chest pain [42], its role in cocaine-related ischemia and infarction remains unclear and requires further investigation.