Comparison of activation process of platelets and neutrophils after coronary stent implantation versus balloon angioplasty for stable angina pectoris☆
Section snippets
Patients
The subjects were 48 consecutive patients with isolated atherosclerotic coronary artery disease of the proximal left anterior descending artery who underwent initial elective coronary angioplasty. All of the patients exhibited clinically stable class I or II effort angina without previous myocardial infarction, according to the Canadian Cardiovascular Society. The target lesions were all type A or type B lesions as described by the American College of Cardiology/American Heart Association Task
Results of coronary intervention
In the balloon angioplasty group, 2 patients underwent stent implantation in bailout situations. Thus, 22 patients in the balloon angioplasty group were eligible for data analysis. In 3 patients in the stent group, the Palmatz-Schatz stent could not be advanced to the lesion, so other stents were implanted. Thus, a total of 21 patients in the stent group were eligible for data analysis. None of these 21 patients experienced acute or subacute stent thrombosis.
Baseline characteristics, procedural variables, and quantitative coronary angiographic results
The clinical background was similar
Platelet activation after coronary stenting
Flow cytometric analysis of platelet activation markers such as P-selectin (CD62P) and CD63 expressed on the platelet membrane surface has facilitated the direct detection of platelets activated in vivo.17 P-selectin is an adhesion molecule included in the selectin family, which potentially binds to leukocyte carbohydrate ligands and mediates adhesion of activated platelets to neutrophils and monocytes.18, 19, 20 P-selectin is a component of the α-granule of resting platelets that is only
Acknowledgements
We thank Richard A. Schatz, MD, Scripps Clinic, La Jolla, California, for his critical review of this manuscript and Gregory J. del Zoppo, MD, Scripps Research Institute, La Jolla, California, for helpful suggestions.
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This study was supported by grants from Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan, and the Vehicle Racing Commemorative Foundation, Tokyo, Japan. Manuscript received February 2, 2000; revised manuscript received and accepted May 31, 2000.