Angiotensin II and atherosclerosis
Section snippets
Oxidative stress as a mechanistic link between angiotensin II and atherosclerosis
Perhaps the most intriguing aspect of the Ang II-mediated events in the arterial wall is the almost complete overlap with proposed mechanisms of atherogenesis. Many of the phenomena implicated in atherosclerosis can be reproduced by Ang II. Atherosclerosis is an inflammatory disease of vascular wall initiated and amplified by vascular oxidative stress.9 Ang II is also a very potent stimulus for both inflammation and oxidative stress.2 The important potential sources of oxidative stress in
Conclusion
In summary there is accumulating evidence from both clinical studies and laboratory investigations that the renin–angiotensin II system represents a critical, causal link in the pathogenesis of human atherosclerosis. The current studies provide mechanistic insights into the precise role of Ang II in atherosclerosis, which suggest that pharmacologic interventions involving the renin–angiotensin system may be of fundamental importance in the treatment and prevention of atherosclerosis.
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