Research articleEarly detection of successful coronary reperfusion based on serum concentration of human heart-type cytoplasmic fatty acid-binding protein
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Cited by (28)
Evaluation of Different Blood Parameters From Endurance Horses Competing at 160 km
2021, Journal of Equine Veterinary ScienceCitation Excerpt :Another less well-known blood parameter in horses is heart fatty acid binding protein (HFABP). This protein is normally involved in active fatty acid transport in cardiac myocytes [19–21]. In humans, HFABP, which is released from cardiomyocytes after an ischemic episode, is used as an early sensitive cardiac biomarker [19–21].
The predictive value of heart-type fatty acid-binding protein is independent from symptom duration in normotensive patients with pulmonary embolism
2013, Thrombosis ResearchCitation Excerpt :These subgroups exhibited no significant differences in demographic parameters, comorbidities, risk factors, or 30-day outcome. Based on its rapid release after myocardial cell damage and its fast renal clearance from circulation, H-FABP has been reported to be a sensitive marker for the detection of reperfusion after thrombolytic treatment of acute myocardial infarction [16] with high predictive accuracy as early as 15 minutes after treatment [17] and for the detection of re-infarction [10]. In patients with acute myocardial infarction, H-FABP plasma concentration return to normal within 20-24 hours after symptom onset [9–11]; however, in our PE patient population, 18.7% of the patients with duration of symptoms ≥ 24 hours had H-FABP levels ≥ 6 ng/ml on admission.
The role of the heart-type fatty acid binding protein in the early diagnosis of acute coronary syndrome and its comparison with troponin i and creatine kinase-MB isoform
2010, American Journal of Emergency MedicineCitation Excerpt :The shorter one will be more valuable in the management of patients with AMI potential just after the start of symptoms. The usefulness of H-FABP as a biochemical marker should be used in searching the clogged coronary artery to be recanalized [24], in estimating the infarct area [25,26], and in estimating the myocardial damage during cardiac surgery [27]. Finally, we have indicated that it could be possible to ascertain H-FABP concentration in peripheral bloods of patients with ACS, especially in the hyperacute phase soon after symptoms started and that it could be beneficial in the diagnosis of ACS.
Prognostic Value of a Multimarker Approach for Patients Presenting to Hospital With Acute Chest Pain
2009, American Journal of CardiologyCitation Excerpt :However, it was considered necessary given that thrombolysis has the potential to alter levels of hemostatic markers and markers of myocyte injury such as H-FABP.12,13
Performance of a semi-quantitative whole blood test for human heart-type fatty acid-binding protein (H-FABP)
2005, Clinical BiochemistryFatty acid-binding proteins as plasma markers of tissue injury
2005, Clinica Chimica ActaCitation Excerpt :Following successful reperfusion both plasma H-FABP and myoglobin were found to rise sharply, whereas in patients with failed reperfusion, these markers rise at a slower rate, but generally relatively low sensitivities and specificities (approximately 70%) were found. Normalization to infarct size improved these to approximately 80%, indicating their suitability in retrospective studies with known infarct size [118,121]. Some studies suggest that H-FABP also can be useful for early detection of postoperative myocardial tissue loss in patients undergoing coronary bypass surgery [93,122–126].