Neovascularization and coronary atherosclerotic plaque: Cinematographic localization and quantitative histologic analysis**
References (16)
- et al.
Cellular and vascular manifestations of cell-mediated immunity
Hum Pathol
(1986) What is the role of myocardial mast cells?
Hum Pathol
(1985)- et al.
Hypothesis: vasa vasorum and neovascularization of human coronary arteries: a possible role in the pathophysiology of atherosclerosis
N Engl J Med
(1984) - et al.
Tubular organization and vascular-tubular relations in the dog kidney
Am J Physiol
(1975) - et al.
Cutaneous basophil hypersensitivity: II. A light and electron microscopic description
J Exp Med
(1970) Endarteritis and arteritis
Berl Klin Wochenschr
(1876)- et al.
- et al.
Vasculature in the walls of human coronary arteries
Arch Pathol Lab Med
(1985)
Cited by (85)
Mechanisms of Xiong-Pi-Fang in treating coronary heart disease associated with depression: A systematic pharmacology strategy and in vivo pharmacological validation
2022, Journal of EthnopharmacologyCitation Excerpt :During hypoxia, phosphorylated STAT3 directly binds to HIF-1α and upregulates its stability by delaying HIF-1α degradation and accelerating protein synthesis (Jung et al., 2005). HIF-1α plays a significant role in angiogenesis, occurring in arteriosclerosis by inducing the angiogenic factor VEGF (Kamat et al., 1987; Sluimer and Daemen, 2009) expression, mediating significant alterations associated with atherogenesis and angiogenic activity of macrophages (Kruth et al., 2002). Similarly, IL-6 regulates the JAK2/STAT3 pathway to control the expression of various neurotransmitter receptors and related pathway proteins, thereby contributing to the pathogenesis of depression.
Vascular calcification: New insights into endothelial cells
2021, Microvascular ResearchCitation Excerpt :EC metabolic changes can also induce angiogenesis, and neovascularization represents a channel of material transport that can induce VC (Hackett et al., 2016; Evdokimenko et al., 2018). In the 1980s, researchers found a potential correlation between angiogenesis and ectopic calcification in atherosclerotic lesions (Kamat et al., 1987). Numerous networks of new nourishing blood vessels exist in areas of intimal thickening and obvious calcification, and the number of neovascularization events is related to disease severity.
Hypoxia inducible factor as a therapeutic target for atherosclerosis
2018, Pharmacology and TherapeuticsCitation Excerpt :There is a clear correlation between the growth and potential rupture of the atherosclerotic plaque and the expression of VEGF and HIF. Research indicates that adventitial microvessels are more numerous in vulnerable and older plaques, implying that the HIF and the angiogenic pathway is key in atherosclerosis and the progression to its life-threatening complications (Kamat, Galli, Barger, Lainey, & Silverman, 1987; Lappalainen, Laine, Pentikainen, Sajantila, & Kovanen, 2004; Mofidi et al., 2001; Moreno et al., 2004; Sluimer & Daemen, 2009). Nuclear HIF-1α has been found to be present in atherosclerotic plaques, suggesting that HIF-1α was in its active form in these areas, and translocated to the nucleus in order to induce transcription of genes.
- **
Supported by grants HL 02493, HL 31632, HL 19467, and AI 22674 from the US Public Health Service; and by gifts from R.J.R. Nabisco and SmithKline Beckman Corporation.
- *
from the Department of Pathology, Beth Israel Hospital and Harvard Medical School, Harvard Medical School, Boston, Massachusetts
- †
Charles A. Dana Research Institute, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts
- ‡
the Department of Physiology and Biophysics, Harvard Medical School, Boston, Massachusetts
- §
from the Department of Medicine, Beth Israel Hospital and Harvard Medical School, Harvard Medical School, Boston, Massachusetts