Original contributionMyoglobin as an early indicator of acute myocardial infarction
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Cited by (111)
Feasibility and Reliability of Rapid Diagnosis of Myocardial Infarction
2020, American Journal of the Medical SciencesCardiac markers of myocardial necrosis. A history and discussion of milestones and emerging new trends
2014, Clinics in Laboratory MedicineCitation Excerpt :Because of its kinetic pattern of release, myoglobin was used in the 1990s and early 2000s as an early marker of myocardial necrosis. In an early study, myoglobin testing at admission to the emergency department detected 57% of myocardial infarctions and testing at 3 hours after admission permitted detection of 100% of cases.6 Myoglobin was particularly helpful when used in conjunction with other more specific cardiac markers (eg, CK-MB and troponin) in multimarker panels, and accelerated rule-out myocardial infarction protocols (discussed later).
Update on the use of cardiac markers in the diagnosis of acute coronary syndrome
2013, Journal of Acute MedicineTakotsubo cardiomyopathy has a unique cardiac biomarker profile: NT-proBNP/myoglobin and NT-proBNP/troponin T ratios for the differential diagnosis of acute coronary syndromes and stress induced cardiomyopathy
2012, International Journal of CardiologyCitation Excerpt :However, NT-proBNP/myoglobin ratio has a sensitivity of 89% at a specificity of 90% for discrimination of TC from STEMI and a sensitivity of 65% at a specificity of 90% to distinguish TC from NSTEMI. In this context, it is important to be aware that myoglobin levels will peak approximately 2 to 6 h after onset of pain [13, 14]. Of note, to distinguish acute coronary syndromes from Takotsubo at the highest specificity and sensitivity, the use of the peak NT-proBNP/peak TnT ratio appeared most accurate.
Evaluation of the chest pain patient: Survey of current practice patterns
2010, Journal of Emergency MedicineRole of biochemical markers in diagnosis of myocardial infarction
2005, International Journal of Cardiology
This work was supported in part by the Proctor & Gamble Company, Cincinnati, Ohio.
Presented at the American College of Emergency Physicians, Scientific Assembly, Atlanta, September 1986.