Clinical study: pediatric cardiology
Myocardial perfusion and function of the systemic right ventricle in patients after atrial switch procedure for complete transposition: long-term follow-up

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Abstract

OBJECTIVES

Our purpose was to assess the right ventricular (RV) function and identify patients with RV impairment long after the Mustard or Senning operation.

BACKGROUND

Systemic ventricular failure can cause myocardial perfusion abnormalities in thallium scintigraphy correlating with hemodynamic deterioration.

METHODS

Myocardial perfusion at rest and at peak exercise was assessed in 61 patients, aged 7 to 23 years in mean time 10.0 ± 2.9 years after surgery using technetium-99m methoxyisobutyl isonitrile single-photon emission computed tomography. Ventricular function was assessed by first-pass radionuclide angiography at rest. Exercise capacity was determined with a modified Bruce protocol.

RESULTS

The mean RV ejection fraction was 36.1 ± 7.7%, and left ventricular (LV) ejection fraction was 52.1 ± 9.4%. Moderate or severe perfusion abnormalities on the rest scan were observed in 20 patients (33%). On exercise perfusion worsened in another 13 patients (21.3%). Patients with perfusion defects on stress scan had significantly lower RV and LV ejection fraction (33.2 vs. 39.4%; p = 0.002 and 49.2 vs. 55.5%; p = 0.01, respectively). They were also older (16.6 vs.13.0 years; p = 0.002), operated on at an older age (4.0 vs. 2.4 years; p = 0.05) and had longer follow-up (12.5 vs. 10.5 years; p = 0.003).

CONCLUSIONS

Myocardial perfusion defects are common findings in patients in long-term follow-up after atrial switch operation. Despite excellent exercise tolerance, the extent of myocardial perfusion abnormalities correlated well with impaired RV and LV function, and greater perfusion defects were seen more frequently in older patients with longer follow-up. It is likely that myocardial perfusion defects could be a sensitive predictor of systemic ventricular impairment.

Abbreviations

ECG
electrocardiogram
LVEF
left ventricular ejection fraction
LV
left ventricle or ventricular
LVOTO
left ventricular outflow tract obstruction
RVEF
right ventricular ejection fraction
RV
right ventricle or ventricular
SD
standard deviation
SPECT
single-photon emission computed tomography
TGA
complete transposition
VSD
ventricular septal defect

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Supported by Grant 4P05C 042 11 from the Scientific Research Committee, Warsaw, Poland.