Clinical study
Troglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with non–insulin dependent diabetes mellitus: A serial intravascular ultrasound study

https://doi.org/10.1016/S0735-1097(00)00895-0Get rights and content
Under an Elsevier user license
open archive

Abstract

OBJECTIVES

The aim of the present study was to determine whether troglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with non–insulin dependent diabetes mellitus (NIDDM).

BACKGROUND

Increased in-stent restenosis in patients with diabetes mellitus is due to accelerated neointimal tissue proliferation after coronary stent implantation. Troglitazone inhibits intimal hyperplasia in experimental animal models.

METHODS

We studied 62 stented lesions in 52 patients with plasma glucose levels (PG) ≥11.1 mmol/liter at 2 h after 75 g oral glucose load. The study patients were randomized into two groups: the troglitazone group of 25 patients with 29 stents, who were treated with 400 mg of troglitazone, and the control group of 27 patients with 33 stents. All patients underwent oral glucose tolerance tests before and after their six-month treatment period. The sum of PG (ΣPG) and the sum of insulin levels (ΣIRI) were measured. Serial (postintervention and at six-month follow-up) intravascular ultrasound studies were performed. Cross-sectional images within stents were taken at every 1 mm, using an automatic pullback. Stent areas (SA), lumen areas (LA), and intimal areas (IA = SA − LA) were measured and averaged over a number of selected image slices. The intimal index was calculated as intimal index = averaged IA/averaged SA × 100%.

RESULTS

There were no differences between the two groups before treatment in ΣPG (31.35 ± 3.07 mmol/liter vs. 32.89 ± 4.87 mmol/liter, respectively, p = 0.2998) and ΣIRI (219.6 ± 106.2 mU/liter vs. 209.2 ± 91.6 mU/liter, respectively, p = 0.8934). However, reductions in ΣPG at the six-month follow-up in the troglitazone group were significantly greater than those in the control group (−21.4 ± 8.8% vs. −4.5 ± 7.4%, respectively, p < 0.0001). Likewise, decreases in ΣIRI were greater in the troglitazone-treated group (−31.4 ± 17.9% vs. −1.9 ± 15.1%, respectively, p < 0.0001). Although, there were no differences between the two groups in SA at postintervention (7.4 ± 2.2 mm2 vs. 7.3 ± 1.7 mm2, respectively, p = 0.9482) and at follow-up (7.3 ± 2.3 mm2 vs. 7.3 ± 1.8 mm2, respectively, p = 0.2307), the LA at follow-up in the troglitazone group was significantly greater than that in the control group (5.3 ± 1.7 mm2 vs. 3.7 ± 1.7 mm2, respectively, p = 0.0002). The IA at follow-up in the troglitazone group was significantly smaller than that in the control group (2.0 ± 0.9 mm2 vs. 3.5 ± 1.8 mm2, respectively, p < 0.0001). This was also true for intimal index (27.1 ± 11.5% vs. 49.0 ± 14.4%, respectively, p < 0.0001).

CONCLUSIONS

Serial intravascular ultrasound assessment shows that administration of troglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with NIDDM.

Abbreviations

DM
diabetes mellitus
HDL
high-density lipoprotein
IA
intimal areas
IGT
impaired glucose tolerance
IRI
immunoreactive insulin level
IVUS
intravascular ultrasound
LA
cross-sectional lumen areas
LDL
low-density lipoprotein
MLD
minimal lumen diameter
NIDDM
non-insulin dependent diabetes mellitus
OGTT
oral glucose tolerance test
PDGF
platelet-derived growth factor
PG
plasma glucose level
SA
cross-sectional stent areas
VSMC
vascular smooth muscle cell

Cited by (0)