Coronary artery diseaseGender Differences in Acute Non–ST-Segment Elevation Myocardial Infarction
Section snippets
The ACOS registry
The ACOS registry was a prospective German multicenter registry investigating the current treatment of acute coronary syndromes. The 155 participating hospitals were located in Germany and included university hospitals, community hospitals, and tertiary care centers, all providing intensive care units and medical reperfusion therapy, some with facilities for cardiac catheterization and balloon angioplasty. During the entire study, all patients with acute coronary syndromes were registered
Baseline characteristics
From June 2000 to December 2002, a total of 6,358 consecutive patients with NSTEMIs were admitted to 154 participating hospitals. One third of all patients were women (n = 2,168). Women were 7.5 years older than men. Women less often had a history of myocardial infarction, PCI, coronary artery bypass grafting, and renal failure. They less often were smokers compared with men. Systemic hypertension, diabetes mellitus, and obesity were more often present in women. After age adjustment, there was
Discussion
After correction for age, there was no difference in hospital and long-term mortality for NSTEMI between men and women, although acute PCI was performed less often in women and women less often were treated with glycoprotein IIb/IIIa antagonists and clopidogrel.
In accordance with studies of acute coronary syndromes,3, 4, 5, 6, 7, 8, 9, 10, 11 our study showed that women and men with NSTEMIs were different in their risk profiles: women were older than men by an average of 7.5 years and had a
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This study was supported by a grant from MSD Sharp & Dohme, Haar, Germany.