MiscellaneousCardiac Structure and Function in Persons 85 Years of Age
Section snippets
Methods
Subjects were recruited from the Jerusalem Longitudinal Cohort Study, which was initiated in 1990 and has followed an age-homogenous cohort of West Jerusalem residents born from June 1920 to May 1921. The method has been described elsewhere in detail.2, 3 In the present study, we examined data from the third most recent phase of data collection, which took place during 2005 and 2006. Subjects were interviewed and examined in their homes on 2 separate occasions, each session requiring the
Results
Of the 450 subjects, 219 were men and 231 were women. Clinical characteristics of the study group are listed in Table 1. Most of the sample (77%) was of Ashkenazi (European) Jewish origin, with 23% of Sephardic (Middle Eastern or North African) Jewish origin. The average body mass index in our cohort was 27.1 mg/kg2, slightly lower than that noted in other Western populations. There was a high prevalence of hypertension and ischemic heart disease, as expected in this elderly cohort, but most
Discussion
In this study, we define for the first time cardiac morphology, systolic function, and diastolic function in a representative sample of a community-dwelling cohort of 85-year-olds. This cohort demonstrated enlarged left atria as well as very elevated LV mass, with significant concentric remodeling. We confirm previous findings regarding general age-related deterioration of diastolic function in this very elderly cohort not previously well studied and provide new insight into systolic
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2020, JACC: Cardiovascular ImagingCitation Excerpt :Certain community-based studies have selectively studied elder populations, and questioned whether mild dysfunction is simply a phenotype of the aging heart, and not pathological (8,53). Of note, there is a parallel increase in the prevalence of enlarged LA, increased LV mass, and a relatively elevated estimated systolic pulmonary artery pressures suggesting chronically elevated LV diastolic pressures in the elderly, likely in the context of chronically elevated systolic blood pressures (53–56). Sex-related differences in diastolic measurements have been reported, though overall prevalence appears similar in men and women.
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2012, American Journal of CardiologyCitation Excerpt :Several previous studies have described an age-related decrease in diastolic function.20–25 We have previously demonstrated that this deterioration is present independently of concomitant cardiovascular morbidity, as evidenced by the finding of relatively elevated E/e′ ratios even in a healthy subgroup of subjects aged 85 years.25 Conversely, systolic function as assessed by the EF has been shown to be normal with aging.26
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This work was supported by funds from the Ministry of Labor and Social Affairs of the State of Israel, Jerusalem, Israel; the Association for the Planning and Development of Services for the Aged in Israel, New York, New York; the National Insurance Institute, Jerusalem, Israel; and various private charitable donors.