EditorialShould C-reactive protein be measured routinely during acute myocardial infarction?
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Cited by (13)
Residual Inflammatory Risk and its Association With Events in East Asian Patients After Coronary Intervention
2022, JACC: AsiaCitation Excerpt :After several weeks, hsCRP gradually returns to baseline but remains elevated in some patients for longer periods.13 To use hsCRP as a reliable RIR biomarker, its measurement may be delayed for at least 4 to 6 weeks after an MI to permit resolution of the acute-phase reaction.34 The recent PCI data including our registry data have suggested clinical usefulness of RIR assessment based on serial hsCRP measurement,14,16 which may reduce the risk of misunderstanding for the realistic RIR phenotype.
Erythrocyte Sedimentation Rate and C-Reactive Protein
2012, Hospital Medicine ClinicsCitation Excerpt :However, it is not clear how much incremental value it provides above traditional risk factors or prognostic elements. For instance, its true ability to predict 30-day mortality after an acute myocardial infarction, above and beyond that of prognostic factors such as the creatinine kinase peak, electrocardiogram, and cardiac ejection fraction, is unclear.64 The same can be said for use of CRP in acute ischemic stroke, namely that CRP concentrations are predictive of future cardiovascular events, but whether adding CRP levels to time-honored prognostic factors should change management is unknown.5
C-Reactive Protein and Heart Failure after Myocardial Infarction in the Community
2007, American Journal of MedicineCitation Excerpt :It is unlikely related to recurrent ischemia because the associations between CRP and heart failure and death were not altered by adjusting for recurrent ischemic events. Alternative explanations include an exaggerated immune response to myocardial injury,32-34 as demonstrated by the association of inflammatory cytokines with ventricular remodeling after myocardial infarction, ejection fraction, and heart failure progression.33,35,36 Finally, experimental animal studies showed that CRP may have direct harmful effects on the ischemic myocardium.
Early inflammation and risk of long-term development of heart failure and mortality in survivors of acute myocardial infarction: Predictive role of C-reactive protein
2006, Journal of the American College of CardiologyCitation Excerpt :C-reactive protein levels might further increase in patients with unstable angina, owing to widespread vascular inflammation (17), and are associated with recurrent clinical instability and recurrent infarctions (18); however, in unstable coronary disease the rise in CRP and other markers of inflammation such as interleukin-6 occurs almost exclusively in patients with evidence of myocardial necrosis (7,8). Thus myocardial necrosis seems to elicit a more pronounced activation of CRP that is superimposed on the low-grade, vascular-mediated inflammation (6,8). Because the extent of CRP elevation in patients with MI is dominated by the inflammatory response to myocardial injury rather than vascular inflammation, it has been associated with mortality but not with recurrent infarctions (9,12,19,20).
Usefulness of C-reactive protein as a marker of early post-infarct left ventricular systolic dysfunction
2012, Inflammation Research