Clinical investigationHeart failure/cardiomyopathyAssessment of Longitudinal and Radial Ventricular Dyssynchrony in Ischemic and Nonischemic Chronic Systolic Heart Failure: A Two-Dimensional Echocardiographic Speckle-Tracking Strain Study
Section snippets
Methods
The study enrolled 95 patients in chronic, stable, NYHA functional class II to IV with a LV EF of 40% or less, and a LV end-diastolic diameter of 55 mm or greater. In all, 11 patients were excluded from the analysis because of suboptimal echocardiographic images. Patients were selected for the study in stable, optimally pharmacologically treated, condition. None of the patients were congestive at the time of the echocardiographic examination. The study was in compliance with the rules of the
Study Groups
Between May and September 2005, 95 consecutive patients presenting with chronic systolic HF (LV EF ≤40%, and LV end-diastolic diameter ≥55 mm) were included in this study. The underlying heart disease was ischemic cardiomyopathy (ICM) in 46 patients non-ICM (NICM) in 49 patients. The baseline characteristics of the two study groups are presented in Table 1, as are the characteristics of the control population.
Mean LV EF and QRS duration were similar in both groups. All patients were optimally
Discussion
This study showed that ventricular DYS can be assessed by analyzing longitudinal and radial 2D-STS from a single apical view. This new means of myocardial mechanical properties quantification is very promising. Different profiles of DYS were found, which were influenced by the underlying cause of HF. ICM and NICM appeared to have different myocardial contractile behaviors that resulted in different electromechanical correlates.
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