Letter to the EditorCumulative exercise-induced left ventricular systolic and diastolic dysfunction in hypertrophic cardiomyopathy☆
References (7)
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Mortality from hypertrophic cardiomyopathy in England and Wales: clinical and screening implications
Int J Cardiol
(2004) Hypertrophic cardiomyopathy: a systematic review
JAMA
(2002)- et al.
Recommendations for competitive sports participation in athletes with cardiovascular disease: a consensus document from the Study Group of Sports Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology
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Cited by (10)
Controversies Surrounding Exercise in Genetic Cardiomyopathies
2018, Heart Failure ClinicsCitation Excerpt :In this study, the primary determinant of poor cardiac reserve was failure of stroke volume augmentation. In an earlier study, exercise-induced myocardial dysfunction was associated with clinical deterioration and worse outcomes.74 Although these studies show that poor exercise capacity is a predictor of adverse outcomes in HCM patients, whether exercise could accelerate or, on the other hand, attenuate the progression of disease, is unknown.
Exercise in patients with hypertrophic cardiomyopathy: A review of current evidence, national guideline recommendations and a proposal for a new direction to fitness
2017, Journal of Science and Medicine in SportCitation Excerpt :Similar observations of cardiac fibrosis were reproduced in a rat model of long term intensive exercise training.37 In patients with HCM, intensive and rigorous exercise has been hypothesized to result in disease progression through promotion of LVH and myocardial ischemia leading to myocardial fibrosis as well as development of LV systolic and diastolic dysfunction.38 Interestingly, however, the results of a study using a mouse model of HCM contradict this belief.39
Sports and Exercise in Athletes with Hypertrophic Cardiomyopathy
2015, Clinics in Sports MedicineCitation Excerpt :These studies suggest that the risk of SCD associated with exercise is grossly overestimated in practice. There is also a hypothetical consideration that vigorous exercise could promote the progression of the underlying HCM disease process through myocardial ischemia or the development of LV systolic or diastolic dysfunction.40–42 High-intensity exercise training has also been shown to promote the development of AF, and athletes with HCM may be more predisposed than athletes with a structurally normal heart.43,44
Hypertrophic cardiomyopathy
2017, Cardiology in the YoungEffects of exercise on arrhythmia (and Viceversa): Lesson from the greek mythology
2017, Advances in Experimental Medicine and BiologyMyocardial energy depletion and dynamic systolic dysfunction in hypertrophic cardiomyopathy
2016, Nature Reviews Cardiology
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This paper was presented in part at the Annual Scientific Session of the American College of Cardiology, 6–9 March, 2004, New Orleans, Louisiana.