Clinical ResearchCardiac ImagingHypoxia But Not Inflammation Augments Glucose Uptake in Human Macrophages: Implications for Imaging Atherosclerosis With 18Fluorine-Labeled 2-Deoxy-D-Glucose Positron Emission Tomography
Cardiac Imaging
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Key Words
atherosclerosis
fluorodeoxyglucose
glucose transporter
hexokinase
hypoxia
inflammation
positron emission tomography
statin
2-deoxy-D-glucose
Abbreviations and Acronyms
acLDL
acetylated low-density lipoprotein
EC
endothelial cell
FdG
18fluorine-labeled 2-deoxy-D-glucose
GLUT
glucose transporter
HIF
hypoxia-inducible factor
HK
hexokinase
HLA
human leukocyte antigen
IFN
interferon
LDL
low-density lipoprotein
mRNA
messenger ribonucleic acid
PET
positron emission tomography
RNA
ribonucleic acid
RT-qPCR
reverse transcription–quantitative polymerase chain reaction
siRNA
small interfering ribonucleic acid
SMC
smooth muscle cell
TNF
tumor necrosis factor
2dG
2-deoxy-D-glucose
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Financial support for this project was provided by the Donald W. Reynolds Foundation (Las Vegas, NV). Dr. Christen is an employee of Boston Scientific. All other authors have reported that they have no relationships to disclose. Drs. Folco and Sheikine contributed equally to this work.
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.