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The Insulin-Like Growth Factors (IGFs) and IGF Binding Proteins in Postnatal Development of Murine Mammary Glands

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Abstract

The insulin-like growth factors are mitogens and survival factors for normal mammary epithelialcells in vitro. Data reviewed here demonstrate that mRNAs for IGF-I and IGF-II, the IGFtype I receptor and the IGFBPs are expressed locally in mammary tissue during pubertal andpregnancy-induced growth and differentiation of murine mammary glands. IGF-I, IGF-II andthe IGF-IR were expressed in terminal end buds (TEBs) in virgin glands during ductal growth.In addition, IGF-II and IGF-IR mRNAs were expressed in ductal and alveolar epithelium inglands throughout postnatal development. Consistent with these results, IGF-I promoted ductalgrowth and proliferation in mouse mammary glands in organ culture. In addition to endogenousexpression of the IGFs and IGF-IR, the IGFBPs showed a varied pattern of expression inmammary tissue during postnatal development. For example, IGFBP-3 and -5 mRNAs wereexpressed in TEBs and ducts while IGFBP-2 and -4 mRNAs were expressed in stromal cellsimmediately surrounding the epithelium. These results support a role for the IGFs and IGFBPsas local mediators of postnatal mammary gland growth and differentiation.

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  1. Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania

    Teresa L. Wood, Monica M. Richert, Malinda A. Stull & Michael A. Allar

  2. Department of Neuroscience and Anatomy H109, PSU/College of Medicine, P.O. Box 850, Hershey, Pennsylvania, 17033

    Teresa L. Wood

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Wood, T.L., Richert, M.M., Stull, M.A. et al. The Insulin-Like Growth Factors (IGFs) and IGF Binding Proteins in Postnatal Development of Murine Mammary Glands. J Mammary Gland Biol Neoplasia 5, 31–42 (2000). https://doi.org/10.1023/A:1009511131541

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