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Ibutilide

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Cardiac Electrophysiology Review

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References

  1. Lee KS. Ibutilide, a new compound with potent class III antiarrhythmic activity, activates a slow inward Na+ current in guinea pig ventricular cells. J Pharmacol Exp Ther 1992;262:99-108.

    Google Scholar 

  2. Yang T, Snyders DJ, Roden DM. Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly-activating delayed rectifier K+ current (IKr) in AT-1 cells. Circulation 1995;91:1799-1806.

    Google Scholar 

  3. Lynch JJ, Baskin EP, Nutt EM, et al. Comparison of binding to rapidly activating delayed rectifier K+ channel, Ikr, and effects on myocardial refractoriness for class III antiarrhythmic agents. J Cardiovasc Pharmacol 1995;25:336- 340.

    Google Scholar 

  4. Cimini MG, Brunden MN, Gibson JK. Effects of ibutilide fumarate, a novel antiarrhythmic agent, and its enantiomers on isolated rabbit myocardium. Eur J Pharmacol 1992; 222:93-98.

    Google Scholar 

  5. Buchanan LV, LeMay RJ, Walters RR, et al. Antiarrhythmic and electrophysiologic effects of intravenous ibutilide and sotalol in the canine sterile pericarditis model. J Cardiovasc Electrophysiol 1996;7:113-119.

    Google Scholar 

  6. Stambler BS, Wood MA, Ellenbogen KA. Antiarrhythmic actions of intravenous ibutilide compared with procainamide during human atrial flutter and fibrillation. Electrophysiological determinants of enhanced conversion efficacy. Circulation 1997;96:4298-4306.

    Google Scholar 

  7. Buchanan LV, Lemay RJ, Gibson JK. Comparison of the antiarrhythmic agents d,l-sotalol HCl and ibutilide fumarate for atrial reverse use dependence and antiarrhythmic effects. PACE 1996;19:687. (Abstract).

    Google Scholar 

  8. Stambler BS, Beckman KJ, Kadish AH, et al. Acute hemodynamic effects of intravenous ibutilide in patients with or without reduced left ventricular function. Am J Cardiol 1997;80:458-463.

    Google Scholar 

  9. Ellenbogen KA, Stambler BS, Wood MA, et al. Efficacy of intravenous ibutilide for rapid termination of atrial fibrillation and atrial flutter: a dose response study. J Am Coll Cardiol 1996;28:130-136.

    Google Scholar 

  10. Stambler BS, Wood MA, Ellenbogen K, et al. Efficacy and safety of repeated intravenous doses of ibutilide for rapid conversion of atrial flutter or fibrillation. 1996; 94:1613-1621.

    Google Scholar 

  11. Mattioni T, Denker S, Riggio D, et al. Efficacy and safety of intravenous ibutilide in the treatment of atrial flutter and atrial fibrillation following valvular or coronary artery bypass surgery. PACE 1997;20:1059. (Abstract).

    Google Scholar 

  12. Volgman AS, Carberry PA, Stambler BS, et al. Conversion efficacy and safety of intravenous ibutilide compared with intravenous procainamide in patients with atrial flutter or fibrillation. J Am Coll Cardiol 1998;31:1414-1419.

    Google Scholar 

  13. Stambler BS, Wood MA, Ellenbogen KA. Comparative efficacy of intravenous ibutilide versus procainamide for enhancing termination of atrial flutter by atrial overdrive pacing. Am J Cardiol 1996;77:960-966.

    Google Scholar 

  14. Wesley RC, Farkhani F, Morgan D, Zimmerman D. Ibutilide: enhanced defibrillation via plateau sodium current activation. Am J Physiol 1993;264:H1269-H1274.

    Google Scholar 

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Authors and Affiliations

  1. Department of Medicine/Cardiology, West Roxbury Veterans Affairs Medical Center, Harvard Medical School, West Roxbury, MA

    Bruce S. Stambler

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  1. Bruce S. Stambler
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Stambler, B.S. Ibutilide. Card Electrophysiol Rev 2, 173–175 (1998). https://doi.org/10.1023/A:1009967713885

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