Abstract
Nitric oxide (NO) modulates the biological activity of proteins by direct interactions with their iron centres. It can also S-nitrosylate cysteines to form S-nitrosothiols. Such reactions affect the activity of membrane-bound, cytosolic and nuclear proteins including the NMDA receptor1, haemoglobin2 and transcription factors such as NF-κB3 and OxyR. NO is potentially toxic, inducing both apoptosis and necrosis. Here we show that NO-mediated S-nitrosylation of the cysteine-containing enzymes that mediate apoptosis (caspases and tissue-transglutaminase, tTG) regulates the balance between apoptosis and necrosis.
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References
Lipton, S. A.et al. Nature 364,626–632(1993).
Jia, L., Bonaventura, C., Bonaventura, J. & Stamler, J. S. Nature 380,221–226(1996).
Matthews, J. R.et al. Nucleic Acids Res. 24,2236–2242(1996).
Kumar, S. & Lavin, M. F. Cell Death Differ. 3,255–267(1996).
Nicholson, D. W.et al. Nature 376,37–43(1995).
Melino, G.et al. Mol. Cell. Biol. 14,6584–6596(1994).
Dimmler, S., Haendeler, J., Nehls, M. & Zeiher, A. M. J. Exp. Med. 185,601–607(1997).
Ankarcrona, M.et al. Neuron 15,961–973(1995).
Lizasoain, I., Moro, M. A., Knowles, R. G., Darley-Usmar, V. & Moncada, S. Biochem. J. 314,877–880(1996).
Kroemer, G., Petit, P., Zamzami, N., Vayssiere, J. -L. & Mignotte, B. FASEB J. 9,1277–1287(1995).
Kluck, R. M., Bossy-Wetzel, E., Green, D. R. & Newmeyer, D. D. Science 275,1132–1136(1997).
Tabuchi, A., Sano, K., Tsuchiya, T. & Tsuda, M. FEBS Lett. 351, 123-127 (1994).
Lipton, S. A. Nature Med. 3,20–22(1997).
Smeyne, R. J.et al. Nature 363,166–169(1993).
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Melino, G., Bernassola, F., Knight, R. et al. S-nitrosylation regulates apoptosis. Nature 388, 432–433 (1997). https://doi.org/10.1038/41237
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DOI: https://doi.org/10.1038/41237
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