Thorac Cardiovasc Surg 2005; 53(3): 138-143
DOI: 10.1055/s-2005-837453
Original Cardiovascular

© Georg Thieme Verlag KG Stuttgart · New York

Brain Natriuretic Peptide Release in Cardiac Surgery Patients

A.-M. Sinha1 , O.-A. Breithardt1 , M. Schmid2 , C. Stellbrink1
  • 1Department of Cardiology, University Hospital, RWTH Aachen, Aachen, Germany
  • 2Clinic of Cardiovascular and Thoracic Surgery, University Hospital, RWTH Aachen, Aachen, Germany
Further Information

Publication History

Received August 23, 2004

Publication Date:
30 May 2005 (online)

Abstract

Brain natriuretic peptide (BNP) release is a marker of increased myocardial wall tension, which is elevated in patients with disturbed left ventricular function. As it is increasingly being used as a reliable marker for diagnosis, optimization of pharmacological treatment, and risk stratification, BNP measurement might be also relevant for patients undergoing cardiac surgery. Measured BNP levels can be used to predict postoperative complications and the risk of further cardiac events. Preoperative BNP levels support the decision for the timing of aortic valve replacement in asymptomatic severe aortic stenosis. An increase in BNP levels early predicts allograft rejection after cardiac transplantation or ineffective cardiac resynchronization therapy. Moreover, BNP levels can be used to differentiate between cardiac and non-cardiac reasons for acute dyspnea in the management of surgical patients. Finally, the application of recombinant human BNP seems to improve recovery after cardiac surgical procedures.

Thus, BNP can be a helpful tool for monitoring and treating patients before, during, and after cardiac surgery to predict and improve the effectiveness of therapy and reduce hospitalization and costs.

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Dr. Dr. Anil-Martin Sinha

II. Medizinische Klinik
Klinikum Coburg GmbH

Ketschendorfer Straße 33

96450 Coburg

Germany

Phone: + 499561220

Fax: + 49 95 61 22 72 20

Email: amsinha@gmx.de

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