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Alcohol and high-density-lipoprotein cholesterol:a randomized controlled trial

Published online by Cambridge University Press:  09 March 2007

Michael L. Burr ,
Ann M. Fehily ,
Barbara K. Butland ,
Colin H. Bolton  and
Robert D. Eastham
Michael L. Burr
Affiliation:
MRC Epidemiology Unit, 4 Richmond Road, Cardir CF2 3AS
Ann M. Fehily
Affiliation:
MRC Epidemiology Unit, 4 Richmond Road, Cardir CF2 3AS
Barbara K. Butland
Affiliation:
MRC Epidemiology Unit, 4 Richmond Road, Cardir CF2 3AS
Colin H. Bolton
Affiliation:
Department of Medicine, University of Bristol, Bristol
Robert D. Eastham
Affiliation:
Department of Haematology, Frenchay Hospital, Bristol
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Abstract

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1. A randomized controlled trial of cross-over design was set up to examine the effect of alcohol on blood lipids and certain haematological variates relevant to ischaemic heart disease.

2. One hundred subjects drank some alcohol for 4 weeks (mean intake 18.4 g/d) and abstained totally for 4 weeks, the order of these periods being randomized.

3. Alcohol appeared to produce a rise of 7% in serum high-density-lipoprotein(HDL) cholesterol, probably due to a rise in the HDL2 subfraction.

4. No significant change was detected in plasma fibrinogen or the other haematoiogical indices.

5. These results are consistent with the hypothesis that a moderate intake of alcohol confers some protection against heart disease.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 56 , Issue 1 , July 1986 , pp. 81 - 86
Copyright
Copyright © The Nutrition Society 1986

References

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