Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
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Emotional Stress Induces Transient Left Ventricular Hypocontraction in the Rat Via Activation of Cardiac Adrenoceptors
A Possible Animal Model of `Tako-Tsubo' Cardiomyopathy
Takashi UeyamaKen KasamatsuTakuzo HanoKatsuhiro YamamotoYoshihiro TsuruoIchiro Nishio
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2002 Volume 66 Issue 7 Pages 712-713

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Abstract

The etiology of a novel cardiac syndrome `tako-tsubo' cardiomyopathy, otherwise known as `transient left ventricular (LV) apical ballooning' and which mimics acute myocardial infarction, is not clear; however, emotional or physical stress is known to precede the attack. Left ventriculography of rats experiencing emotional stress induced reversible LV apical ballooning, which was normalized by pretreatment with adrenoceptor blockade. Together with results of previous studies, activation of cardiac adrenoceptors in the absence of ischemia-reperfusion is proposed as the primary cause of this syndrome. (Circ J 2002; 66: 712 - 713)

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© 2002 THE JAPANESE CIRCULATION SOCIETY
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