Circadian Variation of the Onset of Acute Myocardial Infarction in the Osaka Area, 1998-1999 Characterization of Morning and Nighttime Peaks

Kunihiro Kinjo; Hideyuki Sato; Hiroshi Sato; Issei Shiotani; Toshiya Kurotobi; Yozo Ohnishi; Eiji Hishida; Daisaku Nakatani; Hiroshi Ito; Yukihiro Koretsune; Atsushi Hirayama; Jun Tanouchi; Masahiro Mishima; Tsunehiko Kuzuya; Hiroshi Takeda; Masatsugu Hori; The Osaka Acute Coronary Insufficiency Study (OACIS) Group

doi:10.1253/jcj.65.617

Clinical Investigation

Circadian Variation of the Onset of Acute Myocardial Infarction in the Osaka Area, 1998-1999

Characterization of Morning and Nighttime Peaks

Kunihiro Kinjo, Hideyuki Sato, Hiroshi Sato, Issei Shiotani, Toshiya Kurotobi, Yozo Ohnishi, Eiji Hishida, Daisaku Nakatani, Hiroshi Ito, Yukihiro Koretsune, Atsushi Hirayama, Jun Tanouchi, Masahiro Mishima, Tsunehiko Kuzuya, Hiroshi Takeda, Masatsugu Hori, The Osaka Acute Coronary Insufficiency Study (OACIS) Group

Author information

Kunihiro Kinjo
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
Hideyuki Sato
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
Hiroshi Sato
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
Issei Shiotani
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
Toshiya Kurotobi
Osaka Police Hospital
Yozo Ohnishi
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
Eiji Hishida
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
Daisaku Nakatani
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
Hiroshi Ito
Sakurabashi Watanabe Hospital
Yukihiro Koretsune
Osaka National Hospital
Atsushi Hirayama
Osaka Police Hospital
Jun Tanouchi
Osaka Police Hospital
Masahiro Mishima
Osaka Rosai Hospital
Tsunehiko Kuzuya
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
Hiroshi Takeda
Kawachi General Hospital
Masatsugu Hori
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
The Osaka Acute Coronary Insufficiency Study (OACIS) Group
Author's Organization：
Department of Medical Information Science, Osaka University Graduate School of Medicine

Keywords: Acute myocardial infarction, Alcohol, Cigarette smoking, Circadian variation, Japanese, Trigger

JOURNAL FREE ACCESS

2001 Volume 65 Issue 7 Pages 617-620

DOI https://doi.org/10.1253/jcj.65.617

Details

Abstract

The onset of acute myocardial infarction (AMI) shows characteristic circadian variations; that is, a definite morning peak related to biologic rhythms and a vague nighttime peak related to socioeconomic factors. The recent economic recession in Japan may change the circadian variation, especially the nighttime peak. This study evaluated the recent circadian variation of AMI in Osaka and specified the patient subgroups showing either a morning or nighttime peak predominantly. Of 1,609 consecutive patients with AMI registered from April 1998 to January 2000, 1,252 whose onset of AMI was definitely identified were studied. The day was divided into six 4-h periods with a morning peak between 08.01 h and 12.00 h, and nighttime peak between 20.01 h and 24.00 h. When subgroup analysis was performed, female patients aged 65 years or more showed a morning peak alone and male patients aged less than 65 years with an occupation and the habits of cigarette smoking and alcohol intake showed a nighttime peak alone. Thus, in Osaka nighttime socioeconomic factors may currently be more potent triggers of AMI than the morning surges in younger male workers who smoke and drink. (Jpn Circ J 2001; 65: 617 - 620)

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