Chest
Cardiology Practice TodayIncidence of Heart Failure in 2,737 Older Persons With and Without Diabetes Mellitus
Section snippets
Materials and Methods
We investigated in a prospective study the association between diabetes mellitus and new CHF in 865 men and 1,872 women, with a mean age of 81 ± 9 years (range, 60 to 103 years), in a long-term health-care facility. Diabetes mellitus was present if the patient was receiving insulin (n = 360) or oral hypoglycemic drugs (n = 237) to control hyperglycemia or if the fasting venous plasma glucose levels were ≥140 mg/dL on two occasions (n = 93).9
Patients were considered at entry into the study to
Results
Follow-up was 43 ± 24 months (range, 1 to 160 months). CHF developed in 739 of 2,737 patients (27%). Table 1 shows the baseline characteristics and incidence of CHF in 690 patients with diabetes mellitus and in 2,047 patients without diabetes mellitus and levels of statistical significance. Table 2 shows the Cox regression analysis for the development of CHF.
Discussion
Diabetes mellitus is a risk factor for CHF independent of other risk factors.1,2,3,4,5,6,7,8 The data from this prospective study of 2,737 older patients show that age, hypertension, CAD, male gender, and diabetes mellitus were significantly positively associated with the time to the development of CHF. There was a 1.26 times higher chance of developing CHF for an increment of 5 years of age after controlling the confounding effects of other prognostic variables. Patients with CAD had a 4.0
References (9)
- et al.
Diabetic cardiomyopathy
Prog Cardiovasc Dis
(1985) - et al.
Diabetic cardiomyopathy
Am Heart J
(1989) - et al.
Role of diabetes in congestive heart failure: the Framingham Study
Am J Cardiol
(1974) - et al.
Increased congestive heart failure after myocardial infarction of modest extent in patients with diabetes mellitus
Am Heart J
(1984)
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2020, European Journal of PharmacologyCitation Excerpt :Moreover, the RR with type 1 diabetes in men was 3.47 (2.57, 4.69) and 5.15 in women (3.43, 7.74), with an RRR of 1.47 (1.90, 1.44) (Azoulay and Suissa, 2017). The risk of HF was found to be significantly higher in women than men with diabetes mellitus, which further complements the findings of Framingham Heart Study (Azoulay and Suissa, 2017; Aronow and Ahn, 1999). Moreover, an observational study conducted for 43 months suggested that the incidence of clinically confirmed HF was 39% in diabetic patients versus 23% in non-diabetics (Bertoni et al., 2006).
Heart Failure and Diabetes Mellitus: Defining the Problem and Exploring the Interrelationship
2019, American Journal of Cardiology
Presented at CHEST 1998, the 64th Annual International Scientific Assembly of the American College of Chest Physicians, Toronto, ON, Canada, November 1998.