Chest
Clinical InvestigationsSleepAdhesion Molecules in Patients With Coronary Artery Disease and Moderate-to-Severe Obstructive Sleep Apnea
Section snippets
Subjects
Seventy-two consecutive patients referred for evaluation of CAD at the Veterans Affairs Medical Center of Western New York were recruited for participation in the study. All study participants were free from previous stroke, transient ischemic attack, and cancer at study entry. Patients with valvular heart disease, cardiomyopathy (left ventricular ejection fraction ≤ 45%), malignant arrhythmias, severe pulmonary disease (FEV1 < 1.0 L), or those who were receiving oxygen or continuous positive
Results
Baseline clinical characteristics of patients and control subjects were similar for age, gender, anthropometric measurements, and major risk factors (Table 1). Patients with OSA and those without OSA did not differ in the use of β-blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, or lipid-lowering agents. The angiographic data were comparable in the two groups after controlling for the number of coronary arteries diseased (Table 2). In particular, the difference in
Discussion
The results of this study demonstrate the following: (1) circulating adhesion molecules are significantly elevated in CAD patients with moderate-to-severe OSA compared to those without OSA, and (2) the concentration of circulating adhesion molecules correlated with the severity of sleep apnea and the desaturation index but not with the severity of hypoxemia or the frequency of arousals.
Epidemiologic studies17,18 have suggested an association between OSA and systemic hypertension independent of
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This study was supported by a grant from the Research for Health in Erie County and Veterans Affairs enhancement funds.