Chest
Clinical InvestigationsPneumoniaThe Community-Acquired Pneumonia Symptom Questionnaire: A New, Patient-Based Outcome Measure To Evaluate Symptoms in Patients With Community-Acquired Pneumonia
Section snippets
Questionnaire Development
We interviewed 33 patients with CAP in the United States and France to identify content domains and questions for the CAP-Sym. The interview sample included patients at different stages of the condition: from onset to up to 7 days after onset (5 US patients, 2 French patients), 8 to 21 days after onset (10 US patients, 7 French patients), and at the end of oral antimicrobial treatment (at least 28 days after onset; 5 US patients, 4 French patients). The patients’ mean age was 52 years, and 58%
Respondent Characteristics
As shown in Table 2, a total of 556 patients from 13 countries completed the baseline assessment. The sample included 321 men (58%) and 235 women (42%), who ranged in age from 17 to 97 years (mean, 50.41 years).
Item Reduction
The unrotated principal component factor analysis confirmed that items were measuring a single construct. One item (coughing up blood) that did not load on the first unrotated factor > 0.30 was sufficiently near to this criterion (0.27) to support this assumption. There was a low
Discussion
The CAP-Sym is a practical and scientifically sound patient-based outcome measure of CAP-related symptoms that has been developed using “gold standard” methods. As the only fully validated measure of symptoms in CAP, which is quick and easy to administer and is more responsive than the generic SF-36, the CAP-Sym provides a rigorous method for improving the evaluation of treatment outcomes in CAP. A short questionnaire that takes < 2 min to complete, it can be easily incorporated into clinical
APPENDIX
Acknowledgment
We thank the study investigators in each of the clinical sites.
References (46)
- et al.
The cost of treating community acquired pneumonia
Clin Ther
(1998) Community acquired pneumonia: epidemiology, etiology, treatment
Infect Dis Clin North Am
(1998)- et al.
Effects of a practice guideline for community-acquired pneumonia in an outpatient setting
Am J Med
(2001) - et al.
Decreased mortality after implementation of a treatment guideline for community-acquired pneumonia
Am J Med
(2001) - et al.
Oral moxifloxacin vs high-dosage amoxicillin in the treatment of mild-to-moderate, community-acquired pneumococcal pneumonia in adults
Chest
(2001) - et al.
Relation between length of hospital stay and costs of care for patients with community-acquired pneumonia
Am J Med
(2000) - et al.
Evaluating quality-of-life and health status instruments: development of scientific criteria
Clin Ther
(1996) - et al.
The international index of erectile dysfunction (IIEF): a multidimensional scale for assessment of erectile dysfunction
Urology
(1997) - et al.
How should we measure function in patients with chronic heart and lung disease?
J Chronic Dis
(1985) - et al.
Psychometric evaluation of the CAP-Sym questionnaire: a new, patient-based measure of symptoms in community-acquired pneumonia
Value Health
(2001)
Guidelines for the management of community acquired pneumonia in adults admitted to hospital: The British Thoracic Society
Br J Hosp Med
Community acquired pneumonia
N Engl J Med
Practice guidelines for the management of community-acquired pneumonia in adults
Clin Infect Dis
Canadian guidelines for the initial management of community acquired pneumonia: an evidence-based update by the Canadian Infectious Diseases Society and the Canadian Thoracic Society
Clin Infect Dis
ERS Task Force Report: guidelines for management of adult community-acquired lower respiratory tract infections; European Respiratory Society
Eur Respir J
Guidelines for the management of adults with community-acquired pneumonia: diagnosis, assessment of severity, antimicrobial therapy, and prevention
Am J Respir Crit Care Med
Management of community-acquired pneumonia in the era of pneumococcal resistance
Arch Intern Med
Medical outcomes and antimicrobial costs with the use of the American Thoracic Society guidelines for outpatients with community-acquired pneumonia
JAMA
Clinical effectiveness of a combination of bromhexine and amoxicillin in lower respiratory tract infection
Drug Res
Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelines
Thorax
Influence of age on symptoms at presentation in patients with community-acquired pneumonia
Arch Intern Med
A controlled trial of a critical pathway for treatment of community-acquired pneumonia
JAMA
Measuring symptomatic and functional recovery in patients with community-acquired pneumonia
J Gen Intern Med
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This work was funded by Bayer plc. Drs. Lamping and Schroter have received research funding and support for attending con- ferences from Bayer. MAPI Values (Dr. Marquis and Ms. Marrel) has received funding from Bayer for consulting, questionnaire development, and linguistic validation.