Abstract
This study examined whether the adenosine receptor antagonist theophylline prevents the warm-up phenomenon in patients with stable angina undergoing serial exercise tests. Our findings offer evidence that adenosine does not play a role in the warm-up phenomenon, and indirectly suggest that the warm-up phenomenon does not represent ischemic preconditioning in humans.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Adenosine / physiology*
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Adult
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Aged
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Angina Pectoris / physiopathology*
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Coronary Angiography / drug effects
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Coronary Disease / physiopathology
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Cross-Over Studies
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Double-Blind Method
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Electrocardiography / drug effects
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Exercise Test / drug effects*
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Female
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Humans
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Infusions, Intravenous
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Ischemic Preconditioning, Myocardial*
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Male
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Middle Aged
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Purinergic P1 Receptor Antagonists*
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Theophylline / pharmacology*
Substances
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Purinergic P1 Receptor Antagonists
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Theophylline
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Adenosine