Comparison of a 60- versus 90-minute determination of ST-segment resolution after thrombolytic therapy for acute myocardial infarction. In TIME-II Investigators. Intravenous nPA for Treatment of Infarcting Myocardium Early-II

J A de Lemos; E M Antman; R P Giugliano; D A Morrow; C H McCabe; S S Cutler; A Charlesworth; R Schröder; E Braunwald

doi:10.1016/s0002-9149(00)01207-8

Comparison of a 60- versus 90-minute determination of ST-segment resolution after thrombolytic therapy for acute myocardial infarction. In TIME-II Investigators. Intravenous nPA for Treatment of Infarcting Myocardium Early-II

Am J Cardiol. 2000 Dec 1;86(11):1235-7, A5. doi: 10.1016/s0002-9149(00)01207-8.

Authors

J A de Lemos¹, E M Antman, R P Giugliano, D A Morrow, C H McCabe, S S Cutler, A Charlesworth, R Schröder, E Braunwald

Affiliation

¹ Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

PMID: 11090796
DOI: 10.1016/s0002-9149(00)01207-8

Abstract

Determination of ST-segment resolution 60 minutes after the administration of thrombolytic therapy allows accurate risk stratification for mortality and congestive heart failure. Patients with complete ST resolution at 60 minutes tended to be at lower risk for 30-day mortality than patients with complete ST resolution at 90 minutes.

Publication types

Clinical Trial
Comparative Study
Evaluation Study
Multicenter Study
Randomized Controlled Trial

MeSH terms

Aspirin / therapeutic use
Double-Blind Method
Drug Therapy, Combination
Electrocardiography / drug effects*
Female
Fibrinolytic Agents / therapeutic use
Follow-Up Studies
Heparin / therapeutic use
Humans
Male
Middle Aged
Myocardial Infarction / drug therapy
Myocardial Infarction / physiopathology*
Odds Ratio
Plasminogen Activators / therapeutic use*
Prognosis
Thrombolytic Therapy*
Tissue Plasminogen Activator / therapeutic use*

Substances

Fibrinolytic Agents
lanoteplase
Heparin
Plasminogen Activators
Tissue Plasminogen Activator
Aspirin