Association of white blood cell count with increased mortality in acute myocardial infarction and unstable angina pectoris. OPUS-TIMI 16 Investigators

C P Cannon; C H McCabe; R G Wilcox; J H Bentley; E Braunwald

doi:10.1016/s0002-9149(00)01444-2

Association of white blood cell count with increased mortality in acute myocardial infarction and unstable angina pectoris. OPUS-TIMI 16 Investigators

Am J Cardiol. 2001 Mar 1;87(5):636-9, A10. doi: 10.1016/s0002-9149(00)01444-2.

Authors

C P Cannon¹, C H McCabe, R G Wilcox, J H Bentley, E Braunwald

Affiliation

¹ Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. cannon@partners.org

PMID: 11230853
DOI: 10.1016/s0002-9149(00)01444-2

Abstract

We observed in a study of 7,651 patients with acute coronary syndromes that a white blood cell (WBC) count of > 10,000 was associated with increased 30-day and 10-month mortality (6.2% vs 3.2% to 3.6% for WBC count < 10,000; p < 0.000). With its simplicity and widespread availability, WBC count could serve as a simple, inexpensive, new tool for risk stratification in acute coronary syndromes.

Publication types

Clinical Trial
Comparative Study
Multicenter Study
Randomized Controlled Trial

MeSH terms

Aged
Alanine / administration & dosage
Angina, Unstable / drug therapy
Angina, Unstable / immunology
Angina, Unstable / mortality*
Female
Follow-Up Studies
Humans
Leukocyte Count*
Male
Middle Aged
Myocardial Infarction / drug therapy
Myocardial Infarction / immunology
Myocardial Infarction / mortality*
Platelet Aggregation Inhibitors / administration & dosage
Pyrrolidines / administration & dosage
Risk Factors
Survival Rate

Substances

Platelet Aggregation Inhibitors
Pyrrolidines
orbofiban
Alanine