Transcatheter ventricular septal defect (VSD) occlusion was performed in 55 patients using two disk devices (the buttoned device transvenously and the self-adjustable device transarterially) and wireless devices (transcatheter patch and balloon detachable devices) transvenously. Most of the VSDs were perimembranous (45) and the rest congenital muscular (five) and postinfarction (five). All patients had effective occlusion of their VSDs; two early buttoned device cases had aortic interference and were removed surgically. All the used devices were successful in occluding VSDs; the transvenous approach was lengthier. The transarterial approach was the easiest, although not feasible in all cases. The transcatheter patch appears the most promising for perimembranous defects because of the safety features and minimal rim requirements.