Impaired glucose tolerance as a determinant of early deterioration of left ventricular diastolic function in middle-aged healthy subjects

H Okura; H Inoue; M Tomon; S Nishiyama; T Yoshikawa; K Yoshida; J Yoshikawa

doi:10.1016/s0002-9149(99)00866-8

Impaired glucose tolerance as a determinant of early deterioration of left ventricular diastolic function in middle-aged healthy subjects

Am J Cardiol. 2000 Mar 15;85(6):790-2, A9. doi: 10.1016/s0002-9149(99)00866-8.

Authors

H Okura¹, H Inoue, M Tomon, S Nishiyama, T Yoshikawa, K Yoshida, J Yoshikawa

Affiliation

¹ Department of Internal Medicine, Kobe Rehabilitation Hospital, Kobe, Japan.

PMID: 12000065
DOI: 10.1016/s0002-9149(99)00866-8

Abstract

To clarify the determinants of an abnormal relaxation diastolic pattern assessed by Doppler echocardiography, 131 middle-aged healthy subjects were analyzed. By multivariate logistic regression analysis, fasting insulin levels (p = 0.0016) and peak glucose levels (p = 0.046) were independent predictors of an abnormal relaxation diastolic pattern 2 hours after 75 g OGTT.

MeSH terms

Diastole / physiology
Female
Glucose Intolerance*
Glucose Tolerance Test
Humans
Insulin Resistance
Male
Middle Aged
Ventricular Dysfunction, Left / diagnosis
Ventricular Dysfunction, Left / physiopathology*