Abstract
The aim of the study was to assess whether NGAL and cystatin C could predict contrast-induced nephropathy in non-diabetic patients (n=60, mean age 60+/-11 years) with normal serum creatinine undergoing elective PCI. We found a significant rise in serum NGAL after 2, 4 and 8 h, and in urinary NGAL after 4, 8 and 24 h after PCI. Cystatin C rose significantly 8 and 24 h after the procedure. Prevalence of CIN was 10%. We found 90% sensitivity and 74% specificity of serum and 76% sensitivity and 80% specificity of urinary NGAL increase. NGAL may represent a sensitive early biomarkers of renal impairment after PCI.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Kidney Injury / blood
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Acute Kidney Injury / chemically induced*
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Acute Kidney Injury / urine
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Acute-Phase Proteins
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Analysis of Variance
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Angina Pectoris / therapy*
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Angioplasty, Balloon, Coronary
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Biomarkers / blood
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Biomarkers / urine
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Contrast Media / adverse effects*
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Creatinine / blood
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Cystatin C
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Cystatins / blood*
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Cystatins / urine*
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Female
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Humans
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Kidney Function Tests
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Lipocalin-2
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Lipocalins / blood*
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Lipocalins / urine*
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Male
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Middle Aged
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Predictive Value of Tests
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Proto-Oncogene Proteins
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Sensitivity and Specificity
Substances
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Acute-Phase Proteins
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Biomarkers
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CST3 protein, human
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Contrast Media
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Cystatin C
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Cystatins
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LCN2 protein, human
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Lipocalin-2
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Lipocalins
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Proto-Oncogene Proteins
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Creatinine