Abstract
Investigations regarding plasma and skeletal muscle electrolytes were carried out in 537 patients on long-term diuretic treatment (greater than 1 year) for arterial hypertension (n = 240) and/or congestive heart failure (n = 297). In both groups there were significant decreases in both plasma and skeletal muscle K and Mg, while the muscle Na values as well as the total and extracellular water content of skeletal muscle were increased.
MeSH terms
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Aged
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Benzothiadiazines*
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Body Water / metabolism
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Diuretics
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Electrolytes / metabolism*
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Extracellular Space / metabolism
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Female
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Heart Failure / drug therapy*
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Heart Failure / metabolism
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Humans
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Hypertension / drug therapy*
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Hypertension / metabolism
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Male
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Middle Aged
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Muscles / metabolism*
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Sodium Chloride Symporter Inhibitors / adverse effects
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Sodium Chloride Symporter Inhibitors / therapeutic use*
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Time Factors
Substances
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Benzothiadiazines
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Diuretics
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Electrolytes
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Sodium Chloride Symporter Inhibitors