A comparative flow study has been conducted on two configurations of the Fontan operations for congenital heart defects in which the right ventricle is by-passed. The study was made on rigid in vitro models of the atriopulmonary and cavopulmonary connections under steady-flow conditions. It involved using pressure and flow measurements to determine the pressure-drop coefficient, pressure-energy-loss coefficient and total-energy-loss coefficient. The cavopulmonary model was found to have much lower flow losses compared to the atriopulmonary model, especially at flow rates about 5 l min-1.