Association of a polymorphism of the endothelial constitutive nitric oxide synthase gene with myocardial infarction in the Japanese population

S Ichihara; Y Yamada; T Fujimura; N Nakashima; M Yokota

doi:10.1016/s0002-9149(97)10806-2

Association of a polymorphism of the endothelial constitutive nitric oxide synthase gene with myocardial infarction in the Japanese population

Am J Cardiol. 1998 Jan 1;81(1):83-6. doi: 10.1016/s0002-9149(97)10806-2.

Authors

S Ichihara¹, Y Yamada, T Fujimura, N Nakashima, M Yokota

Affiliation

¹ First Department of Internal Medicine, Nagoya University School of Medicine, Japan.

PMID: 9462613
DOI: 10.1016/s0002-9149(97)10806-2

Abstract

We investigated the association between variations in the endothelial constitutive nitric oxide synthase (ecNOS) gene and the presence of myocardial infarction. The results indicate that the mutant allele (ecNOS'4a) is an independent risk factor for myocardial infarction in the Japanese population, especially in those lacking other conventional risk factors.

MeSH terms

Aged
Asian People / genetics*
Base Sequence
Case-Control Studies
DNA / genetics*
Female
Gene Frequency
Genotype
Humans
Japan
Male
Middle Aged
Myocardial Infarction / enzymology*
Myocardial Infarction / genetics*
Nitric Oxide Synthase / genetics*
Nitric Oxide Synthase Type III
Polymorphism, Genetic / genetics*
Repetitive Sequences, Nucleic Acid / genetics*
Risk Factors

Substances

DNA
NOS3 protein, human
Nitric Oxide Synthase
Nitric Oxide Synthase Type III