Abstract
The role of low-molecular-weight heparins (LMWHs) in the management of stent thrombosis, although expected to produce fewer hemorrhagic complications than warfarin anticoagulation regimens, is poorly defined. The ENoxaparin and TIClopidine after Elective Stenting (ENTICES) trial was designed to compare a combination of a LMWH (enoxaparin), ticlopidine, and aspirin with the conventional warfarin anticoagulant treatment in patients who received coronary stents, in an effort to decrease stent thrombosis and ischemic clinical events. The results show that the enoxaparin regimen produced significantly fewer clinical events and vascular complications than the conventional warfarin anticoagulant regimen.
Publication types
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Clinical Trial
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Comparative Study
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Multicenter Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Aspirin / therapeutic use
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Coronary Angiography
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Coronary Thrombosis / diagnostic imaging
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Coronary Thrombosis / drug therapy*
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Coronary Thrombosis / etiology
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Drug Therapy, Combination
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Enoxaparin / therapeutic use
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Female
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Fibrinolytic Agents / therapeutic use*
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Follow-Up Studies
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Heparin, Low-Molecular-Weight / therapeutic use*
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Humans
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Male
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Middle Aged
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Myocardial Ischemia / diagnostic imaging
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Myocardial Ischemia / surgery
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Platelet Aggregation Inhibitors / therapeutic use
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Stents / adverse effects*
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Ticlopidine / therapeutic use
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Treatment Outcome
Substances
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Enoxaparin
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Fibrinolytic Agents
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Heparin, Low-Molecular-Weight
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Platelet Aggregation Inhibitors
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Ticlopidine
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Aspirin